| Entry |
|
|---|
| Name |
Pirmenol hydrochloride (USAN);
Pirmavar (TN) |
|---|
| Formula |
C22H30N2O. HCl
|
|---|
| Exact mass |
374.2125
|
|---|
| Mol weight |
374.9473
|
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| Structure |
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| Simcomp |
|
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| Class |
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
|
|---|
| Remark |
| Product (DG01381): | D01785<JP> |
|
|---|
| Efficacy |
Antiarrhythmic, Cardiac depressant |
|---|
| Comment |
Class I antiarrhythmic agent (Ia)
|
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| Target |
|
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| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
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| Interaction |
|
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| Structure map |
|
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| Brite |
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG01381 Pirmenol
D06517 Pirmenol hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D06517 Pirmenol hydrochloride (USAN)
SCN2A
D06517 Pirmenol hydrochloride (USAN)
SCN3A
D06517 Pirmenol hydrochloride (USAN)
SCN4A
D06517 Pirmenol hydrochloride (USAN)
SCN5A
D06517 Pirmenol hydrochloride (USAN)
SCN8A
D06517 Pirmenol hydrochloride (USAN)
SCN9A
D06517 Pirmenol hydrochloride (USAN)
SCN10A
D06517 Pirmenol hydrochloride (USAN)
SCN11A
D06517 Pirmenol hydrochloride (USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01649 Class Ia antiarrhythmic agent
DG01381 Pirmenol
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| Other DBs |
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| KCF data |
ATOM 26
1 C8x C 26.8663 -19.6226
2 C8x C 26.8663 -21.0243
3 C8x C 28.0831 -21.7251
4 C8x C 29.2928 -21.0243
5 C8y C 29.2928 -19.6226
6 C8x C 28.0831 -18.9218
7 C1d C 30.5072 -18.9228
8 C8y C 31.7206 -19.6245
9 C8x C 31.7140 -21.0241
10 C8x C 32.9274 -21.7260
11 C8x C 34.1417 -21.0260
12 C8x C 34.1427 -19.6243
13 N5x N 32.9295 -18.9226
14 C1b C 30.5050 -17.5273
15 C1b C 31.7155 -16.8265
16 C1b C 31.7155 -15.4319
17 N1y N 32.9261 -14.7311
18 C1y C 34.1383 -15.4290
19 C1x C 35.3489 -14.7282
20 C1x C 35.3472 -13.3294
21 C1x C 34.1349 -12.6315
22 C1y C 32.9244 -13.3323
23 C1a C 31.7096 -12.6328
24 C1a C 34.1400 -16.8307
25 O1a O 29.2948 -18.2228
26 X Cl 37.2767 -18.6182
BOND 27
1 11 12 1
2 12 13 2
3 13 8 1
4 6 1 1
5 7 14 1
6 14 15 1
7 5 7 1
8 15 16 1
9 16 17 1
10 7 8 1
11 1 2 2
12 2 3 1
13 3 4 2
14 4 5 1
15 5 6 2
16 17 18 1
17 18 19 1
18 19 20 1
19 20 21 1
20 21 22 1
21 22 17 1
22 8 9 2
23 22 23 1 #Down
24 9 10 1
25 18 24 1 #Down
26 10 11 2
27 7 25 1
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