KEGG   DRUG: AmbrisentanHelp
Entry
D07077                      Drug                                   

Name
Ambrisentan (JAN/INN);
Letairis (TN);
Volibris (TN)
Product
  Generic
Formula
C22H22N2O4
Exact mass
378.158
Mol weight
378.4211
Structure
Mol fileKCF fileDB search
Class
Cardiovascular agent
 DG01502  Endothelin receptor antagonist
Metabolizing enzyme substrate
 DG01639  CYP2C19 substrate
 DG02913  CYP3A4 substrate
 DG02925  CYP3A5 substrate
 DG02924  UGT substrate
Transporter substrate
 DG01665  ABCB1 (P-GP) substrate
Remark
Therapeutic category: 2190
ATC code: C02KX02
Product: D07077<JP/US>
Efficacy
Antihypertensive, Endothelin receptor type A antagonist
  Disease
Pulmonary arterial hypertension [DS:H01621]
Target
EDNRA [HSA:1909] [KO:K04197]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Metabolism
Enzyme: UGT1A9 [HSA:54600], UGT2B7 [HSA:7364], UGT1A3 [HSA:54659], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP2C19 [HSA:1557]
Transporter: ABCB1 [HSA:5243]
Interaction
Drug interaction
Structure map
map07229  Angiotensin receptor and endothelin receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02K OTHER ANTIHYPERTENSIVES
    C02KX Antihypertensive for pulmonary arterial hypertension
     C02KX02 Ambrisentan
      D07077  Ambrisentan (JAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Pulmonary Antihypertensives
   Endothelin Receptor Antagonists
    Ambrisentan
     D07077  Ambrisentan (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D07077  Ambrisentan (JAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Endothelin
    EDNRA
     D07077  Ambrisentan (JAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D07077
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D07077
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D07077
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D07077
BRITE hierarchy
Other DBs
CAS: 177036-94-1
PubChem: 51091419
ChEMBL: CHEMBL1111
LigandBox: D07077
NIKKAJI: J2.651.033C
KCF data Show

ATOM        28
            1   C8x C    21.6300  -20.6500
            2   C8x C    21.6300  -22.0500
            3   C8x C    22.8424  -22.7500
            4   C8x C    24.0549  -22.0500
            5   C8y C    24.0549  -20.6500
            6   C8x C    22.8424  -19.9500
            7   C1d C    25.2860  -19.9390
            8   C8y C    26.4912  -20.6347
            9   C8x C    26.4916  -22.0496
            10  C8x C    27.7042  -22.7493
            11  C8x C    28.9165  -22.0489
            12  C8x C    28.9160  -20.6339
            13  C8x C    27.7034  -19.9343
            14  O2a O    24.1597  -19.0972
            15  C1c C    26.0464  -18.7850
            16  C1a C    22.7502  -19.0885
            17  O2a O    27.4396  -18.7934
            18  C6a C    25.3743  -17.5284
            19  O6a O    23.9401  -17.4825
            20  O6a O    26.1159  -16.3347
            21  C8y C    28.1619  -17.5605
            22  N5x N    29.5400  -17.5693
            23  C8y C    30.2478  -16.3614
            24  C8x C    29.5555  -15.1445
            25  C8y C    28.1774  -15.1356
            26  N5x N    27.4697  -16.3436
            27  C1a C    31.6400  -16.3704
            28  C1a C    27.4867  -13.9213
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    7  14 1
            16    7  15 1
            17   14  16 1
            18   15  17 1
            19   15  18 1 #Up
            20   18  19 1
            21   18  20 2
            22   17  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   25  26 2
            28   21  26 1
            29   23  27 1
            30   25  28 1

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