KEGG   DRUG: Phenytoin and phenobarbitalHelp
Entry
D07583            Mixture   Drug                                   

Name
Phenytoin and phenobarbital;
Aleviatin with phenobarbital (TN)
Component
Phenytoin [DR:D00512], Phenobarbital [DR:D00506]
Class
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
Metabolizing enzyme inducer
 DG02891  CYP2B6 inducer
 DG02853  CYP3A inducer
Transporter inducer
 DG01893  ABCB1 (P-GP) inducer
Remark
Therapeutic category: 1139
ATC code: N03AB52
Product: D07583<JP>
Efficacy
Antiepileptic
Comment
Phenytoin is metabolized by CYP2C9 with some contribution from CYP2C19, and it is an inducer of CYP3A, CYP2B6 and P-gp.
Phenobarbital is an inducer of CYP3A.
Metabolism
Enzyme: CYP2C9 [HSA:1559]; CYP2C19 [HSA:1557]
Interaction
CYP induction: CYP3A [HSA:1576 1577 1551], CYP2B6 [HSA:1555]
Transporter induction: ABCB1 [HSA:5243]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AB Hydantoin derivatives
     N03AB52 Phenytoin, combinations
      D07583  Phenytoin and phenobarbital <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D07583  Phenytoin and phenobarbital
BRITE hierarchy
Other DBs
PubChem: 96024446

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