| Entry |
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| Name |
Fosphenytoin sodium hydrate (JAN);
Fostoin (TN) |
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| Formula |
C16H13N2O6P. 7H2O. 2Na
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| Exact mass |
532.1046
|
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| Mol weight |
532.34
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG02031 Hydantoin antiepileptic
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01639 CYP2C19 substrate
Metabolizing enzyme inducer
DG02891 CYP2B6 inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
Transporter inducer
DG01893 ABCB1 inducer
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| Remark |
| Therapeutic category: | 1132 |
| Product (DG00847): | D02096<US> D07595<JP> |
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| Efficacy |
Anticonvulsant |
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| Comment |
Hydantoin derivative
Active form of prodrug: Phenytoin [DR: D00512]
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]; CYP2C19 [HSA: 1557]
|
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576], CYP2B6 [HSA: 1555]
Transporter induction: ABCB1 [HSA: 5243]
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AB Hydantoin derivatives
N03AB05 Fosphenytoin
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
USP drug classification [BR:br08302]
Anticonvulsants
Sodium Channel Agents
Fosphenytoin
D07595 Fosphenytoin sodium hydrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
113 Antiepileptics
1132 Hydantoins
D07595 Fosphenytoin sodium hydrate (JAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG02031 Hydantoin antiepileptic
DG00847 Fosphenytoin
D07595 Fosphenytoin sodium hydrate
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00847 Fosphenytoin
D07595 Fosphenytoin sodium hydrate
DG01639 CYP2C19 substrate
DG00847 Fosphenytoin
D07595 Fosphenytoin sodium hydrate
Metabolizing enzyme inducer
DG02891 CYP2B6 inducer
DG00847 Fosphenytoin
D07595 Fosphenytoin sodium hydrate
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00847 Fosphenytoin
D07595 Fosphenytoin sodium hydrate
Transporter inducer
DG01893 ABCB1 inducer
DG00847 Fosphenytoin
D07595 Fosphenytoin sodium hydrate
Drug classes [BR:br08332]
Neuropsychiatric agent
DG03199 Antiepileptic agent
D07595 Fosphenytoin sodium hydrate
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN2A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN3A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN4A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN5A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN8A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN9A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN10A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN11A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D07595
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07595
Drug transporters
D07595
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG02031 Hydantoin antiepileptic
DG00847 Fosphenytoin
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00847 Fosphenytoin
DG01639 CYP2C19 substrate
DG00847 Fosphenytoin
Metabolizing enzyme inducer
DG02891 CYP2B6 inducer
DG00847 Fosphenytoin
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00847 Fosphenytoin
Transporter inducer
DG01893 ABCB1 inducer
DG00847 Fosphenytoin
Prodrugs [br08324.html]
DG00847
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| Other DBs |
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| KCF data |
ATOM 34
1 O0 O 25.9700 -22.5400
2 Z Na 14.9800 -15.9600 #+
3 Z Na 11.4100 -19.7400 #+
4 C1z C 18.5500 -19.3200
5 N1x N 19.0400 -18.0600
6 C5x C 17.9200 -17.2900
7 N1y N 16.7300 -18.0600
8 C5x C 17.2200 -19.3200
9 O5x O 17.9200 -15.8200
10 O5x O 16.4500 -20.5100
11 C8y C 19.9500 -19.3200
12 C8x C 20.6500 -20.5800
13 C8x C 22.1200 -20.5800
14 C8x C 22.8200 -19.3900
15 C8x C 22.0500 -18.1300
16 C8x C 20.6500 -18.1300
17 C8y C 18.5500 -20.7900
18 C8x C 17.3600 -21.4200
19 C8x C 17.3600 -22.8200
20 C8x C 18.6200 -23.5900
21 C8x C 19.8100 -22.8900
22 C8x C 19.8100 -21.4900
23 C1b C 15.6100 -17.3600
24 O2b O 14.4200 -18.0600
25 P1b P 13.2300 -17.3600
26 O1c O 11.9000 -18.2000 #-
27 O1c O 13.2300 -15.9600 #-
28 O1c O 12.0400 -16.6600
29 O0 O 25.9700 -22.5400
30 O0 O 25.9700 -22.5400
31 O0 O 25.9700 -22.5400
32 O0 O 25.9700 -22.5400
33 O0 O 25.9700 -22.5400
34 O0 O 25.9700 -22.5400
BOND 27
1 4 5 1
2 5 6 1
3 6 7 1
4 7 8 1
5 4 8 1
6 6 9 2
7 8 10 2
8 4 11 1
9 11 12 2
10 12 13 1
11 13 14 2
12 14 15 1
13 15 16 2
14 11 16 1
15 4 17 1
16 17 18 2
17 18 19 1
18 19 20 2
19 20 21 1
20 21 22 2
21 17 22 1
22 23 7 1
23 23 24 1
24 24 25 1
25 25 26 1
26 25 27 1
27 25 28 2
BRACKET 1 23.6600 -23.6600 23.6600 -21.3500
1 26.8100 -21.3500 26.8100 -23.6600
1 7
ORIGINAL 1 1
REPEAT 1 29 30 31 32 33 34
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