| Entry |
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| Name |
Fosphenytoin sodium hydrate (JAN);
Fostoin (TN) |
|---|
| Formula |
C16H13N2O6P. 7H2O. 2Na
|
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| Exact mass |
532.1046
|
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| Mol weight |
532.3445
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| Structure |
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG02031 Hydantoin antiepileptics
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG01639 CYP2C19 substrate
Metabolizing enzyme inducer
DG02891 CYP2B6 inducer
DG01635 CYP3A4 inducer
Transporter inducer
DG01893 ABCB1 (P-GP) inducer
|
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| Remark |
| Therapeutic category: | 1132 |
| Product (DG00847): | D02096<US> D07595<JP> |
|
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| Efficacy |
Anticonvulsant |
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| Comment |
Hydantoin derivative
Active form of prodrug: Phenytoin [DR: D00512]
|
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| Target |
|
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| Pathway |
|
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]; CYP2C19 [HSA: 1557]
|
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| Interaction |
CYP induction: CYP3A4 [HSA: 1576], CYP2B6 [HSA: 1555]
Transporter induction: ABCB1 [HSA: 5243]
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AB Hydantoin derivatives
N03AB05 Fosphenytoin
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
USP drug classification [BR:br08302]
Anticonvulsants
Sodium Channel Agents
Fosphenytoin
D07595 Fosphenytoin sodium hydrate (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
113 Antiepileptics
1132 Hydantoins
D07595 Fosphenytoin sodium hydrate (JAN)
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN2A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN3A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN4A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN5A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN8A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN9A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN10A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
SCN11A
D07595 Fosphenytoin sodium hydrate (JAN) <JP>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D07595
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07595
Drug transporters
D07595
Prodrugs [br08324.html]
DG00847
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| Other DBs |
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| KCF data |
ATOM 34
1 O0 O 25.9700 -22.5400
2 Z Na 14.9800 -15.9600 #+
3 Z Na 11.4100 -19.7400 #+
4 C1z C 18.5500 -19.3200
5 N1x N 19.0400 -18.0600
6 C5x C 17.9200 -17.2900
7 N1y N 16.7300 -18.0600
8 C5x C 17.2200 -19.3200
9 O5x O 17.9200 -15.8200
10 O5x O 16.4500 -20.5100
11 C8y C 19.9500 -19.3200
12 C8x C 20.6500 -20.5800
13 C8x C 22.1200 -20.5800
14 C8x C 22.8200 -19.3900
15 C8x C 22.0500 -18.1300
16 C8x C 20.6500 -18.1300
17 C8y C 18.5500 -20.7900
18 C8x C 17.3600 -21.4200
19 C8x C 17.3600 -22.8200
20 C8x C 18.6200 -23.5900
21 C8x C 19.8100 -22.8900
22 C8x C 19.8100 -21.4900
23 C1b C 15.6100 -17.3600
24 O2b O 14.4200 -18.0600
25 P1b P 13.2300 -17.3600
26 O1c O 11.9000 -18.2000 #-
27 O1c O 13.2300 -15.9600 #-
28 O1c O 12.0400 -16.6600
29 O0 O 25.9700 -22.5400
30 O0 O 25.9700 -22.5400
31 O0 O 25.9700 -22.5400
32 O0 O 25.9700 -22.5400
33 O0 O 25.9700 -22.5400
34 O0 O 25.9700 -22.5400
BOND 27
1 4 5 1
2 5 6 1
3 6 7 1
4 7 8 1
5 4 8 1
6 6 9 2
7 8 10 2
8 4 11 1
9 11 12 2
10 12 13 1
11 13 14 2
12 14 15 1
13 15 16 2
14 11 16 1
15 4 17 1
16 17 18 2
17 18 19 1
18 19 20 2
19 20 21 1
20 21 22 2
21 17 22 1
22 23 7 1
23 23 24 1
24 24 25 1
25 25 26 1
26 25 27 1
27 25 28 2
BRACKET 1 23.6600 -23.6600 23.6600 -21.3500
1 26.8100 -21.3500 26.8100 -23.6600
1 7
ORIGINAL 1 1
REPEAT 1 29 30 31 32 33 34
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