| Entry |
|
|---|
| Name |
Dimetotiazine (INN);
Fonazine;
Migristene (TN) |
|---|
| Formula |
C19H25N3O2S2
|
|---|
| Exact mass |
391.1388
|
|---|
| Mol weight |
391.5507
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
|
|---|
| Remark |
| Product (DG00843): | D01902<JP> |
|
|---|
| Efficacy |
Antimigraine, Serotonin receptor antagonist, H1 receptor antagonist |
|---|
| Comment |
Phenothiazine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02C ANTIMIGRAINE PREPARATIONS
N02CX Other antimigraine preparations
N02CX05 Dimetotiazine
D07854 Dimetotiazine (INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00843 Dimetotiazine
D07854 Dimetotiazine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D07854 Dimetotiazine (INN)
Serotonin
HTR2
D07854 Dimetotiazine (INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00843 Dimetotiazine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 26
1 S2x S 22.3300 -21.4200
2 N1y N 22.3300 -18.6200
3 C8y C 23.5900 -19.3200
4 C8y C 23.5900 -20.7200
5 C8x C 24.7800 -21.4200
6 C8x C 25.9700 -20.7200
7 C8y C 25.9700 -19.3200
8 C8x C 24.7800 -18.6200
9 C8y C 21.1400 -20.7200
10 C8y C 21.1400 -19.3200
11 C8x C 19.9500 -18.6200
12 C8x C 18.6900 -19.3200
13 C8x C 18.6900 -20.7200
14 C8x C 19.9500 -21.4200
15 C1b C 22.3300 -17.2200
16 C1c C 23.5900 -16.5200
17 C1a C 24.7800 -17.2200
18 N1c N 23.5900 -15.1200
19 C1a C 24.7800 -14.4200
20 C1a C 22.3300 -14.4200
21 S4a S 27.2300 -18.6200
22 N1c N 28.4200 -19.3200
23 O3c O 28.2100 -17.6400
24 O3c O 26.2500 -17.6400
25 C1a C 29.6100 -18.6900
26 C1a C 28.4200 -20.7900
BOND 28
1 1 4 1
2 9 10 2
3 10 11 1
4 11 12 2
5 12 13 1
6 13 14 2
7 14 9 1
8 3 2 1
9 2 15 1
10 3 4 2
11 15 16 1
12 4 5 1
13 5 6 2
14 16 17 1
15 16 18 1
16 6 7 1
17 18 19 1
18 7 8 2
19 18 20 1
20 8 3 1
21 2 10 1
22 9 1 1
23 7 21 1
24 21 22 1
25 21 23 2
26 21 24 2
27 22 25 1
28 22 26 1
|
|---|
