| Entry |
|
|---|
| Name |
Doxapram (INN);
Docatone (TN) |
|---|
| Formula |
C24H30N2O2
|
|---|
| Exact mass |
378.2307
|
|---|
| Mol weight |
378.5072
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02925 CYP3A5 substrate
|
|---|
| Remark |
| Product (DG01119): | D01872<JP/US> |
|
|---|
| Efficacy |
Respiratory stimulant |
|---|
| Comment |
Doxapram stimulates carotid body.
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP3A5 [HSA: 1577]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R07 OTHER RESPIRATORY SYSTEM PRODUCTS
R07A OTHER RESPIRATORY SYSTEM PRODUCTS
R07AB Respiratory stimulants
R07AB01 Doxapram
D07873 Doxapram (INN)
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01119 Doxapram
D07873 Doxapram
DG02925 CYP3A5 substrate
DG01119 Doxapram
D07873 Doxapram
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07873
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01119 Doxapram
DG02925 CYP3A5 substrate
DG01119 Doxapram
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 28
1 C8x C 17.7800 -18.9000
2 C8x C 17.7800 -20.3000
3 C8x C 18.9700 -21.0000
4 C8x C 20.2300 -20.3000
5 C8y C 20.2300 -18.9000
6 C8x C 18.9700 -18.2000
7 C8x C 22.6100 -20.3000
8 C8y C 22.6100 -18.9000
9 C1z C 21.4200 -18.2000
10 C8x C 23.8000 -21.0000
11 C8x C 25.0600 -20.3000
12 C8x C 25.0600 -18.9000
13 C8x C 23.8000 -18.2000
14 C1y C 22.5400 -17.3600
15 C1x C 22.1200 -16.0300
16 N1y N 20.7200 -16.0300
17 C5x C 20.3000 -17.3600
18 C1b C 19.9500 -14.8400
19 C1a C 18.5500 -14.8400
20 O5x O 18.9000 -17.3600
21 C1b C 23.9400 -17.3600
22 C1b C 24.6400 -16.1700
23 N1y N 26.0400 -16.1700
24 C1x C 26.7400 -17.3600
25 C1x C 28.1400 -17.3600
26 O2x O 28.8400 -16.1700
27 C1x C 28.1400 -14.9800
28 C1x C 26.7400 -14.9800
BOND 31
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 7 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 8 13 2
15 9 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 9 17 1
20 16 18 1
21 18 19 1
22 17 20 2
23 14 21 1
24 21 22 1
25 22 23 1
26 23 24 1
27 24 25 1
28 25 26 1
29 26 27 1
30 27 28 1
31 23 28 1
|
|---|
