KEGG   DRUG: FludarabineHelp
Entry
D07966                      Drug                                   

Name
Fludarabine (INN);
Fluradosa (TN)
Formula
C10H12FN5O4
Exact mass
285.0873
Mol weight
285.2318
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antineoplastic
 DG01958  Nucleic acid derivative, antineoplastic
  DG01439  Arabinofuranosyl type antineoplastic
 DG01439  Arabinofuranosyl type antineoplastic
 DG02018  Antimetabolite
  DG01958  Nucleic acid derivative, antineoplastic
   DG01439  Arabinofuranosyl type antineoplastic
Remark
Same as: C21550
ATC code: L01BB05
Chemical structure group: DG00685
Product (DG00685): D01907<JP/US>
Efficacy
Antineoplastic, Antimetabolite
Comment
Arabinofuranosyl derivative
Target
RRM1 [HSA:6240] [KO:K10807]
DNA polymerase
RNA polymerase
  Pathway
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
Interaction
Drug interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BB Purine analogues
     L01BB05 Fludarabine
      D07966  Fludarabine (INN)
USP drug classification [BR:br08302]
 Antineoplastics
  Antineoplastics, Other
   Fludarabine
    D07966  Fludarabine (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Ribonucleoside-diphosphate reductase
    RRM1
     D07966  Fludarabine (INN)
Prodrugs [br08324.html]
 D07966
BRITE hierarchy
Other DBs
CAS: 21679-14-1
PubChem: 96024661
ChEMBL: CHEMBL1568
LigandBox: D07966
NIKKAJI: J33.087F
KCF data Show

ATOM        20
            1   C1y C    23.1000  -18.6200
            2   C1y C    24.5000  -18.6200
            3   C1y C    24.9200  -17.2900
            4   O2x O    23.8000  -16.4500
            5   C1y C    22.6800  -17.2900
            6   O1a O    22.4000  -19.8100
            7   O1a O    25.2000  -19.8100
            8   N5x N    27.3000  -18.6900
            9   C8y C    27.3000  -17.2900
            10  N4y N    26.1100  -16.5900
            11  C1b C    21.4900  -16.5900
            12  C8y C    28.4900  -19.3900
            13  N5x N    29.7500  -18.6900
            14  C8y C    29.7500  -17.2900
            15  C8y C    28.4900  -16.5900
            16  N5x N    28.2100  -15.2600
            17  C8x C    26.8800  -15.1200
            18  N1a N    30.8700  -16.5900
            19  X   F    28.4900  -20.7900
            20  O1a O    20.2719  -17.2801
BOND        22
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1 #Down
            7     2   7 1 #Up
            8     8   9 1
            9     9  10 1
            10    3  10 1 #Up
            11    5  11 1 #Up
            12    8  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16    9  15 2
            17   15  16 1
            18   16  17 2
            19   17  10 1
            20   14  18 1
            21   12  19 1
            22   11  20 1

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