KEGG   DRUG: LevobunololHelp
Entry
D08115                      Drug                                   

Name
Levobunolol (INN)
Formula
C17H25NO3
Exact mass
291.1834
Mol weight
291.3853
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
   DG01463  beta3-Adrenergic receptor antagonist
Remark
Same as: C07914
ATC code: S01ED03
Chemical structure group: DG01136
Product (DG01136): D01025<JP/US>
Efficacy
Antiglaucoma, alpha1/beta-Adrenergic receptor antagonist
Comment
Propranolol derivative
Target
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Drug interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED03 Levobunolol
      D08115  Levobunolol (INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Levobunolol
    D08115  Levobunolol (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D08115  Levobunolol (INN)
    ADRB
     D08115  Levobunolol (INN)
BRITE hierarchy
Other DBs
CAS: 47141-42-4
PubChem: 96024805
ChEBI: 6438
ChEMBL: CHEMBL1201237
DrugBank: DB01210
LigandBox: D08115
NIKKAJI: J237.992I
KCF data Show

ATOM        21
            1   C1d C    25.2700  -14.2800
            2   C1a C    26.4600  -15.0500
            3   N1b N    24.0100  -15.0500
            4   C1b C    22.8200  -14.3500
            5   C1c C    21.6300  -14.9800
            6   C1b C    20.4400  -14.3500
            7   O2a O    19.2500  -14.9800
            8   C1a C    25.2700  -12.8800
            9   C1a C    26.4600  -13.5800
            10  O1a O    21.6300  -16.4500
            11  C8y C    19.2500  -16.3800
            12  C8y C    18.0600  -17.0800
            13  C8y C    18.0600  -18.4800
            14  C8x C    19.2500  -19.2500
            15  C8x C    20.4400  -18.5500
            16  C8x C    20.4400  -17.1500
            17  C1x C    16.8000  -16.3800
            18  C1x C    15.6100  -17.0800
            19  C1x C    15.6100  -18.4800
            20  C5x C    16.8000  -19.2500
            21  O5x O    16.8000  -20.6500
BOND        22
            1     1   2 1
            2     1   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     1   8 1
            8     1   9 1
            9     5  10 1 #Down
            10    7  11 1
            11   11  12 2
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   11  16 1
            17   12  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   13  20 1
            22   20  21 2

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