| Entry |
|
|---|
| Name |
Memantine (INN);
Exiba (TN) |
|---|
| Formula |
C12H21N
|
|---|
| Exact mass |
179.1674
|
|---|
| Mol weight |
179.3018
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
DG01968 Antidementia agent
Transporter substrate
DG02854 SLC22A2 substrate
|
|---|
| Remark |
| Product (DG00986): | D04905<JP/US> |
| Product (mixture): | D11387<US> |
|
|---|
| Efficacy |
Dementia therapeutic agent, NMDA receptor antagonist |
|---|
| Comment |
adamantane derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Transporter: SLC22A2 [HSA: 6582]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07056 | Agents for Alzheimer-type dementia |
| map07235 | N-Methyl-D-aspartic acid (NMDA) receptor antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06D ANTI-DEMENTIA DRUGS
N06DX Other anti-dementia drugs
N06DX01 Memantine
D08174 Memantine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
DG00986 Memantine
D08174 Memantine
DG01968 Antidementia agent
DG00986 Memantine
D08174 Memantine
Transporter substrate
DG02854 SLC22A2 substrate
DG00986 Memantine
D08174 Memantine
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Glutamate (ionotropic), NMDA
GRIN (NMDAR)
D08174 Memantine (INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D08174
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D08174
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
DG00986 Memantine
DG01968 Antidementia agent
DG00986 Memantine
Transporter substrate
DG02854 SLC22A2 substrate
DG00986 Memantine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 13
1 C1x C 22.9600 -17.6400
2 C1z C 22.9600 -18.9700
3 C1x C 24.1500 -19.6700
4 C1z C 25.3400 -18.9700
5 C1x C 25.3400 -17.6400
6 C1z C 24.1500 -16.9400
7 C1x C 22.0500 -19.9500
8 C1y C 23.3800 -19.9500
9 C1x C 24.7100 -20.3000
10 C1a C 26.6700 -19.3200
11 C1a C 21.7000 -19.3200
12 N1a N 24.1500 -15.6100
13 C1x C 23.3800 -18.3400
BOND 15
1 2 7 1
2 1 2 1
3 7 8 1
4 2 3 1
5 8 9 1
6 9 4 1
7 3 4 1
8 4 10 1
9 4 5 1
10 2 11 1
11 5 6 1
12 6 12 1
13 6 1 1
14 8 13 1
15 6 13 1
|
|---|
