| Entry |
|
|---|
| Name |
Methyldopa (INN);
Aldomet (TN)
|
|---|
| Formula |
C10H13NO4
|
|---|
| Exact mass |
211.0845
|
|---|
| Mol weight |
211.2145
|
|---|
| Structure |
   |
|---|
| Simcomp |
 |
|---|
| Class |
Cardiovascular agent
DG01738 Centrally-acting antiadrenergic
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
DG01655 alpha2-adrenergic receptor specific agonist
DG01951 Catecholamine adrenergic receptor agonist
Other
DG01617 Catecholamine synthesis inhibitors
|
|---|
| Remark |
| Product (DG00248): | D00405<JP/US> |
| Product (mixture): | D10267<US> |
|
|---|
| Efficacy |
Antihypertensive, alpha2-Adrenergic receptor agonist |
|---|
| Comment |
Peripheral aromatic L-amino acid decarboxylase inhibitors (DCI)
Dopamine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C02 ANTIHYPERTENSIVES
C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING
C02AB Methyldopa
C02AB01 Methyldopa (levorotatory)
D08205 Methyldopa (INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA2
D08205 Methyldopa (INN)
 |
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 15
1 C1d C 27.4400 -15.8200
2 C6a C 28.6300 -15.1200
3 C1b C 26.2500 -15.1200
4 C1a C 26.9500 -17.2200
5 N1a N 28.4200 -17.2200
6 O6a O 29.8200 -15.8200
7 O6a O 28.6300 -13.7900
8 C8y C 25.0600 -15.8200
9 C8x C 23.8700 -15.1200
10 C8x C 25.0600 -17.2200
11 C8y C 22.6800 -15.8200
12 C8x C 23.8700 -17.8500
13 C8y C 22.6800 -17.2200
14 O1a O 21.4900 -15.1200
15 O1a O 21.4900 -17.8500
BOND 15
1 1 2 1
2 1 3 1
3 1 4 1 #Down
4 1 5 1 #Up
5 2 6 1
6 2 7 2
7 3 8 1
8 8 9 1
9 8 10 2
10 9 11 2
11 10 12 1
12 11 13 1
13 11 14 1
14 13 15 1
15 12 13 2
|
|---|
