Entry |
|
Name |
Pioglitazone (INN); Actos (TN) |
Formula |
C19H20N2O3S
|
Exact mass |
356.1195
|
Mol weight |
356.4387
|
Structure |

|
Simcomp |
|
Class |
Antidiabetic agent
DG01685 Insulin sensitizer
DG01795 PPAR gamma agonist
DG01683 Thiazolidinedione
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
|
Remark |
Product (DG00117): | D00945<JP/US> |
Product (mixture): | D09744<JP/US> D09848<JP/US> |
|
Efficacy |
Antidiabetic, Peroxisome proliferator-activated receptor (PPAR) gamma agonist |
Comment |
Thiazolidinedione derivative
|
Target |
|
Pathway |
|
Metabolism |
Enzyme: CYP2C8 [HSA: 1558]
|
Interaction |
|
Structure map |
map07222 | Peroxisome proliferator-activated receptor (PPAR) agonists |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A10 DRUGS USED IN DIABETES
A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BG Thiazolidinediones
A10BG03 Pioglitazone
D08378 Pioglitazone (INN)
Drug groups [BR:br08330]
Antidiabetic agent
DG01685 Insulin sensitizer
DG01795 PPAR gamma agonist
DG01683 Thiazolidinedione
DG00117 Pioglitazone
D08378 Pioglitazone
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00117 Pioglitazone
D08378 Pioglitazone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Thyroid hormone like receptors
Peroxisome proliferator-activated receptor (PPAR)
NR1C3 (PPARG)
D08378 Pioglitazone (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08378
Drug groups [BR:br08330]
Antidiabetic agent
DG01685 Insulin sensitizer
DG01795 PPAR gamma agonist
DG01683 Thiazolidinedione
DG00117 Pioglitazone
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00117 Pioglitazone
|
Other DBs |
|
KCF data |
ATOM 25
1 C1y C 32.9700 -20.3700
2 C1b C 31.7800 -19.6700
3 C8y C 30.5900 -20.3700
4 C8x C 29.3300 -19.6700
5 C8x C 30.5900 -21.7700
6 C8x C 28.1400 -20.3700
7 C8x C 29.3300 -22.4700
8 C8y C 28.1400 -21.7700
9 O2a O 26.9500 -22.4700
10 C1b C 25.6900 -21.7700
11 C1b C 24.5700 -22.4700
12 C8y C 23.3800 -21.7700
13 C8x C 23.3800 -20.3700
14 N5x N 22.1900 -22.4700
15 C8x C 22.1900 -19.6700
16 C8x C 20.9300 -21.7700
17 C8y C 20.9300 -20.3700
18 C1b C 19.7400 -19.6700
19 C1a C 18.5500 -20.3700
20 C5x C 32.9698 -21.7700
21 N1x N 34.3013 -22.2028
22 C5x C 35.1243 -21.0703
23 S2x S 34.3015 -19.9375
24 O5x O 36.5400 -21.0704
25 O5x O 31.8372 -22.5927
BOND 27
1 1 2 1
2 2 3 1
3 3 4 2
4 3 5 1
5 4 6 1
6 5 7 2
7 6 8 2
8 8 9 1
9 9 10 1
10 10 11 1
11 11 12 1
12 12 13 2
13 12 14 1
14 13 15 1
15 14 16 2
16 15 17 2
17 17 18 1
18 18 19 1
19 7 8 1
20 16 17 1
21 1 20 1
22 20 21 1
23 21 22 1
24 22 23 1
25 1 23 1
26 22 24 2
27 20 25 2
|