KEGG   DRUG: PromazineHelp
Entry
D08430                      Drug                                   

Name
Promazine (INN);
Combelen [veterinary] (TN)
Formula
C17H20N2S
Exact mass
284.1347
Mol weight
284.4191
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01905  Phenothiazine antipsychotics
Remark
Same as: C07379
ATC code: N05AA03
Chemical structure group: DG00869
Efficacy
Neuroleptic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AA Phenothiazines with aliphatic side-chain
     N05AA03 Promazine
      D08430  Promazine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D08430  Promazine (INN)
BRITE hierarchy
Other DBs
CAS: 58-40-2
PubChem: 96025116
ChEBI: 8459
ChEMBL: CHEMBL564
DrugBank: DB00420
PDB-CCD: P2Z[PDBj]
LigandBox: D08430
NIKKAJI: J2.805C
KCF data Show

ATOM        20
            1   C8x C    19.9500  -19.0400
            2   C8x C    19.9500  -20.4400
            3   C8x C    21.1400  -21.1400
            4   C8y C    22.4000  -20.4400
            5   C8y C    22.4000  -19.0400
            6   C8x C    21.1400  -18.2700
            7   S2x S    23.5900  -21.1400
            8   C8y C    24.7800  -20.4400
            9   C8y C    24.7800  -19.0400
            10  N4y N    23.5900  -18.2700
            11  C8x C    26.0400  -21.1400
            12  C8x C    27.2300  -20.4400
            13  C8x C    27.2300  -19.0400
            14  C8x C    26.0400  -18.2700
            15  C1b C    23.5900  -16.8700
            16  C1b C    24.7800  -16.1700
            17  C1b C    25.9700  -16.8700
            18  N1c N    27.1600  -16.2400
            19  C1a C    28.3500  -16.8700
            20  C1a C    27.1600  -14.7700
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17   10  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   18  20 1

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