KEGG   DRUG: Dorzolamide hydrochloride and timolol maleateHelp
Entry
D08493            Mixture   Drug                                   

Name
Dorzolamide hydrochloride and timolol maleate;
Cosopt (TN)
Product
  Generic
Component
Dorzolamide hydrochloride [DR:D00653], Timolol maleate [DR:D00603]
Remark
Therapeutic category: 1319
ATC code: S01ED51
Product: D08493<JP/US>
Efficacy
Antiglaucoma
  Disease
Open-angle glaucoma [DS:H00612]
Comment
carbonic anhydrase inhibitor / beta-blocker combination
Dorzolamide is primarily metabolized by CYP2C9, CYP2C19 and CYP3A4.
Timolol is primarily metabolized by CYP2D6.
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED51 Timolol, combinations
      D08493  Dorzolamide hydrochloride and timolol maleate <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Ophthalmic Prostaglandin and Prostamide Analogs
    Dorzolamide Hydrochloride/ Timolol Maleate
     D08493  Dorzolamide hydrochloride and timolol maleate
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D08493  Dorzolamide hydrochloride and timolol maleate
BRITE hierarchy
Other DBs
PubChem: 124490301

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