KEGG   DRUG: SotalolHelp
Entry
D08525                      Drug                                   

Name
Sotalol (INN);
Darob mite (TN)
Formula
C12H20N2O3S
Exact mass
272.1195
Mol weight
272.3638
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01648  Class III antiarrhythmic agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
Remark
Same as: C07309
ATC code: C07AA07
Chemical structure group: DG00307
Product (DG00307): D01026<JP/US>
Efficacy
Antiarrhythmic, beta-Adrenergic receptor antagonist, Potassium channel blocker
Comment
Class III antiarrhythmic agent
Target
ADRB1 [HSA:153] [KO:K04141]
ADRB2 [HSA:154] [KO:K04142]
KCNH2 [HSA:3757] [KO:K04905]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
Interaction
Drug interaction
Structure map
map07037  Antiarrhythmic drugs
map07232  Potassium channel blocking and opening drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA07 Sotalol
      D08525  Sotalol (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB1
     D08525  Sotalol (INN)
    ADRB2
     D08525  Sotalol (INN)
 Ion channels
  Voltage-gated ion channels
   Potassium channels
    KCNH2
     D08525  Sotalol (INN)
BRITE hierarchy
Other DBs
CAS: 3930-20-9
PubChem: 96025210
ChEBI: 63622
ChEMBL: CHEMBL471
DrugBank: DB00489
LigandBox: D08525
NIKKAJI: J10.583J
KCF data Show

ATOM        18
            1   C8y C    24.1500  -17.9900
            2   C1c C    25.3400  -18.6900
            3   C8x C    24.1500  -16.5200
            4   C8x C    22.8900  -18.6900
            5   C1b C    26.5300  -17.9900
            6   O1a O    25.3400  -20.0900
            7   C8x C    22.8900  -15.8200
            8   C8x C    21.7700  -17.9900
            9   N1b N    27.7900  -18.6900
            10  C8y C    21.7700  -16.5200
            11  C1c C    28.9800  -17.9900
            12  N1b N    20.5800  -15.8200
            13  C1a C    30.1700  -18.6900
            14  C1a C    28.9800  -16.5900
            15  S4a S    19.3200  -16.5200
            16  C1a C    18.1300  -15.8200
            17  O3c O    20.5800  -17.2900
            18  O3c O    18.2700  -17.2900
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1
            11   10  12 1
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15   15  16 1
            16   15  17 2
            17   15  18 2
            18    8  10 2

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