KEGG   DRUG: BriobaceptHelp
Entry
D08877                      Drug                                   

Name
Briobacept (USAN)
Formula
C2910H4542N814O878S24
Exact mass
65706.9083
Mol weight
65747.6875
Sequence
DVRRGPRSLR GRDAPAPTPC NPAECFDPLV RHCVACGLLR TPRPKPAGAS SPAPRTALQP
QESVGAGAGE AAVDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS
HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA
LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP
ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPG
(disulfide brige, dimer: 79-79'; 82-82')
  Type
Peptide
Efficacy
Immunosuppressant
Comment
Briobacept is a fusion protein consisting of human BR3 [HSA:115650] [KO:K05151] and human IgG1 Fc.
Treatment of autoimmune disease
Target
TNFSF13B (BAFF, CD257) [HSA:10673] [KO:K05476]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04064  NF-kappa B signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNFSF13B (BAFF, CD257)
     D08877  Briobacept (USAN)
BRITE hierarchy
Other DBs
CAS: 869881-54-9
PubChem: 96025560

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