KEGG   DRUG: PerampanelHelp
Entry
D08964                      Drug                                   

Name
Perampanel (USAN);
Fycompa (TN)
Formula
C23H15N3O
Exact mass
349.1215
Mol weight
349.3847
Structure
Mol fileKCF fileDB search
Class
Neuropsychiatric agent
 DG01569  AMPA receptor antagonist
Metabolizing enzyme substrate
 DG01633  CYP3A substrate
Remark
ATC code: N03AX22
Chemical structure group: DG01901
Product (DG01901): D10780<JP/US>
Efficacy
Antiepileptic, AMPA receptor antagonist
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX22 Perampanel
      D08964  Perampanel (USAN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Glutamate Reducing Agents
   Perampanel
    D08964  Perampanel (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), non-NMDA
    GRIA
     D08964  Perampanel (USAN)
BRITE hierarchy
Other DBs
CAS: 380917-97-5
PubChem: 96025647
ChEBI: 71013
ChEMBL: CHEMBL1214124
PDB-CCD: 6ZP[PDBj]
LigandBox: D08964
KCF data Show

ATOM        27
            1   C8x C    15.7500  -15.1200
            2   C8x C    15.7500  -16.5200
            3   C8y C    16.9624  -17.2200
            4   C8y C    18.1749  -16.5200
            5   C8x C    18.1749  -15.1200
            6   C8x C    16.9624  -14.4200
            7   C8y C    19.4060  -17.2310
            8   C8x C    19.4057  -18.6199
            9   C8y C    20.6180  -19.3202
            10  C8x C    21.8306  -18.6205
            11  N4y N    21.8309  -17.2316
            12  C8y C    20.6186  -16.5313
            13  C3b C    16.9624  -18.6198
            14  N3a N    16.9624  -20.0198
            15  C8y C    23.0553  -16.5251
            16  C8x C    24.2463  -17.2133
            17  C8x C    25.4590  -16.5137
            18  C8x C    25.4595  -15.1137
            19  C8x C    24.2686  -14.4255
            20  C8x C    23.0559  -15.1251
            21  C8y C    20.6177  -20.7196
            22  N5x N    19.4294  -21.4057
            23  C8x C    19.4294  -22.8057
            24  C8x C    20.6419  -23.5057
            25  C8x C    21.8301  -22.8196
            26  C8x C    21.8301  -21.4196
            27  O5x O    20.6187  -15.1204
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 1
            13    7  12 1
            14    3  13 1
            15   13  14 3
            16   11  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   15  20 1
            23    9  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   21  26 1
            30   12  27 2

» Japanese version   » Back

DBGET integrated database retrieval system