KEGG   DRUG: PomalidomideHelp
Entry
D08976                      Drug                                   

Name
Pomalidomide (JAN/USAN/INN);
Pomalyst (TN)
Product
Formula
C13H11N3O4
Exact mass
273.075
Mol weight
273.2441
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cyp substrate
 DG01892  CYP1A2 substrate
Remark
Therapeutic category: 4291
ATC code: L04AX06
Product: D08976<JP/US>
Efficacy
Antineoplastic, Immunomodulator
  Disease
Multiple myeloma [DS:H00010]
Comment
Thalidomide [DR:D00754] analog
Target
TNF (TNFA, TNFSF2) [HSA:7124] [KO:K03156]
IL6 [HSA:3569] [KO:K05405]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04210  Apoptosis
hsa04640  Hematopoietic cell lineage
hsa04650  Natural killer cell mediated cytotoxicity
hsa04660  T cell receptor signaling pathway
hsa04668  TNF signaling pathway
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AX Other immunosuppressants
     L04AX06 Pomalidomide
      D08976  Pomalidomide (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antiangiogenic Agents
   Pomalidomide
    D08976  Pomalidomide (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D08976  Pomalidomide (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interleukins
    IL6
     D08976  Pomalidomide (JAN/USAN/INN) <JP/US>
   Tumor necrosis factors
    TNF (TNFA, TNFSF2)
     D08976  Pomalidomide (JAN/USAN/INN) <JP/US>
Antineoplastics [br08340.html]
 D08976
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D08976
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D08976
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D08976
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D08976
BRITE hierarchy
Other DBs
CAS: 19171-19-8
PubChem: 96025659
ChEBI: 72690
ChEMBL: CHEMBL43452
LigandBox: D08976
KCF data Show

ATOM        20
            1   N1y N    26.1800  -16.0300
            2   C1y C    27.5800  -16.0300
            3   C5x C    25.3400  -17.1500
            4   C5x C    25.3400  -14.9100
            5   C5x C    28.2800  -14.7700
            6   C1x C    28.2800  -17.2200
            7   C8y C    24.0100  -16.7300
            8   O5x O    25.8300  -18.4800
            9   C8y C    24.0100  -15.3300
            10  O5x O    25.7600  -13.5800
            11  N1x N    29.6800  -14.7700
            12  O5x O    27.5800  -13.5800
            13  C1x C    29.7500  -17.2200
            14  C8x C    22.8200  -17.4300
            15  C8y C    22.8200  -14.6300
            16  C5x C    30.3800  -15.9600
            17  C8x C    21.6300  -16.7300
            18  C8x C    21.6300  -15.3300
            19  O5x O    31.7800  -15.9600
            20  N1a N    22.8200  -13.2300
BOND        22
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     4  10 2
            10    5  11 1
            11    5  12 2
            12    6  13 1
            13    7  14 1
            14    9  15 1
            15   11  16 1
            16   14  17 2
            17   15  18 2
            18   16  19 2
            19    7   9 2
            20   13  16 1
            21   17  18 1
            22   15  20 1

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