KEGG   DRUG: Favipiravir
Entry
D09537                      Drug                                   

Name
Favipiravir (JAN/USAN/INN);
Avigan (TN)
Formula
C5H4FN3O2
Exact mass
157.0288
Mol weight
157.1026
Structure
Class
Metabolizing enzyme substrate
 DG02953  AOX substrate
Metabolizing enzyme inhibitor
 DG01641  CYP2C8 inhibitor
 DG02952  AOX inhibitor
Remark
Therapeutic category: 6250
ATC code: J05AX27
Product: D09537<JP>
Efficacy
Antiviral, RNA replicase inhibitor
Comment
Treatment of viral infection (broad-spectrum of anti-RNA virus activities)
Target
RNA-directed RNA polymerase
Metabolism
Enzyme: AOX1 [HSA:316]; XDH [HSA:7498]
Interaction
CYP inhibition: CYP2C8 [HSA:1558]
Enzyme inhibition: AOX1 [HSA:316]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AX Other antivirals
     J05AX27 Favipiravir
      D09537  Favipiravir (JAN/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D09537  Favipiravir (JAN/USAN/INN)
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09537
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09537
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09537
Other DBs
CAS: 259793-96-9
PubChem: 96026217
ChEMBL: CHEMBL221722
LigandBox: D09537
KCF data

ATOM        11
            1   C8x C    17.8500  -21.4200
            2   C8y C    17.8500  -20.0200
            3   N5x N    19.0400  -19.3200
            4   C8y C    20.3000  -20.0200
            5   C8y C    20.3000  -21.4200
            6   N5x N    19.0400  -22.1200
            7   X   F    16.6600  -19.3200
            8   O1a O    21.4900  -22.1200
            9   C5a C    21.4900  -19.3200
            10  N1a N    22.6800  -20.0200
            11  O5a O    21.4900  -17.9200
BOND        11
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     5   8 1
            9     4   9 1
            10    9  10 1
            11    9  11 2

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