KEGG   DRUG: FresolimumabHelp
Entry
D09620                      Drug                                   

Name
Fresolimumab (USAN/INN)
Formula
C6392H9926N1698O2026S44
Exact mass
144297.3591
Mol weight
144386.2278
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGSSVKV SCKASGYTFS SNVISWVRQA PGQGLEWMGG VIPIVDIANY
AQRFKGRVTI TADESTSTTY MELSSLRSED TAVYYCASTL GLVLDAMDYW GQGTLVTVSS
ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES KYGPPCPSCP APEFLGGPSV
FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY
RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK
NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG
NVFSCSVMHE ALHNHYTQKS LSLSLGK
(Light chain)
ETVLTQSPGT LSLSPGERAT LSCRASQSLG SSYLAWYQQK PGQAPRLLIY GASSRAPGIP
DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QYADSPITFG QGTRLEIKRT VAAPSVFIFP
PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS QESVTEQDSK DSTYSLSSTL
TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide bridge: H22-H96, H147-H203, H261-H321, H367-H425, H226-H'226, H229-H'229, L23-L89, L135-L195, H134-L215)
  Type
Peptide
Efficacy
Immunomodulator, Anti-transforming growth factor beta antibody
Comment
Monoclonal antibody
Idiopathic pulmonary fibrosis, focal segmental glomerulosclerosis, and cancer
Target
TGFB [HSA:7040 7042 7043] [KO:K13375 K13376 K13377]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04350  TGF-beta signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Transforming growth factors (RSTK-binding)
    TGFB
     D09620  Fresolimumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 948564-73-6
PubChem: 124490360

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