KEGG   DRUG: Iodine I 124 girentuximab
Entry
D09632                      Drug                                   

Name
Iodine I 124 girentuximab (USAN/INN)
Formula
C6460H(10006-x)IxN1718O2018S48
Sequence
(Heavy chain)
DVKLVESGGG LVKLGGSLKL SCAASGFTFS NYYMSWVRQT PEKRLELVAA INSDGGITYY
LDTVKGRFTI SRDNAKNTLY LQMSSLKSED TALFYCARHR SGYFSMDYWG QGTSVTVSSA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKKVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Light chain)
DIVMTQSQRF MSTTVGDRVS ITCKASQNVV SAVAWYQQKP GQSPKLLIYS ASNRYTGVPD
RFTGSGSGTD FTLTISNMQS EDLADFFCQQ YSNYPWTFGG GTKLEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H146-H202, H263-H323, H369-H427, H228-H'228, H231-H'231, L23-L88, L134-L194, H222-L214)
  Type
Peptide
Efficacy
Diagnostic
Comment
Monoclonal antibody
Diagnosis of clear cell renal cancer
Target
CA9 [HSA:768] [KO:K01672]
Brite
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases (EC4)
   Aldehyde-lyases
    CA9
     D09632  Iodine I 124 girentuximab (USAN/INN)
Other DBs
CAS: 1011710-99-8
PubChem: 124490372

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