| Entry |
|
|---|
| Name |
Rilpivirine (JAN/USAN/INN);
Rekambys (TN) |
|---|
| Formula |
C22H18N6
|
|---|
| Exact mass |
366.1593
|
|---|
| Mol weight |
366.4185
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antiviral
DG01889 Non-nucleoside reverse transcriptase inhibitor (NNRTI)
DG01656 HIV reverse transcriptase inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A substrate
|
|---|
| Remark |
| Product (DG00663): | D09958<JP/US> |
| Product (mixture): | D10836<JP/US> D11966<US> |
|
|---|
| Efficacy |
Antiviral, Reverse transcriptase inhibitor |
|---|
| Target |
HIV-1 reverse transcriptase [KO: K24802] |
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AG Non-nucleoside reverse transcriptase inhibitors
J05AG05 Rilpivirine
D09720 Rilpivirine (JAN/USAN/INN)
Antiinfectives [BR:br08307]
Antivirals
Genome replication inhibitor
HIV reverse transcriptase inhibitor
D09720 Rilpivirine (JAN/USAN/INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D09720
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D09720
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D09720
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 28
1 C8y C 22.1900 -21.7700
2 C8x C 22.1900 -23.1700
3 C8y C 23.4024 -23.8700
4 C8y C 24.6149 -23.1700
5 C8y C 24.6149 -21.7700
6 C8x C 23.4024 -21.0700
7 N1b N 25.8460 -23.8810
8 C8y C 27.0512 -23.1853
9 N5x N 28.2335 -23.8681
10 C8y C 29.4460 -23.1683
11 N5x N 29.4462 -21.7683
12 C8x C 28.2638 -21.0855
13 C8x C 27.0513 -21.7853
14 N1b N 30.6770 -23.8793
15 C8y C 31.8807 -23.1846
16 C8x C 33.0637 -23.8678
17 C8x C 34.2762 -23.1681
18 C8y C 34.2765 -21.7681
19 C8x C 33.0935 -21.0848
20 C8x C 31.8810 -21.7846
21 C1a C 25.8460 -21.0590
22 C3b C 35.5057 -21.0585
23 N3a N 36.7181 -20.3585
24 C2b C 20.9776 -21.0700
25 C2b C 19.7821 -21.7604
26 C3b C 18.5947 -21.0749
27 N3a N 17.3823 -20.3749
28 C1a C 23.4024 -25.2698
BOND 30
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 8 13 2
15 10 14 1
16 14 15 1
17 15 16 1
18 16 17 2
19 17 18 1
20 18 19 2
21 19 20 1
22 15 20 2
23 5 21 1
24 18 22 1
25 22 23 3
26 1 24 1
27 24 25 2
28 25 26 1
29 26 27 3
30 3 28 1
|
|---|
