KEGG   DRUG: BenralizumabHelp
Entry
D09874                      Drug                                   

Name
Benralizumab (USAN/INN);
Benralizumab (genetical recombination) (JAN);
Fasenra (TN)
Product
Formula
C6492H10060N1724O2028S42
Exact mass
145964.5332
Mol weight
146054.4048
Sequence
(Heavy chain) EVQLVQSGAE VKKPGASVKV SCKASGYTFT SYVIHWVRQR
PGQGLAWMGY INPYNDGTKY NERFKGKVTI TSDRSTSTVY MELSSLRSED TAVYLCGREG
IRYYGLLGDY WGQGTLVTVS SASTKGPSVF PLAPSSKSTS GGTAALGCLV KDYFPEPVTV
SWNSGALTSG VHTFPAVLQS SGLYSLSSVV TVPSSSLGTQ TYICNVNHKP SNTKVDKKVE
PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN
WYVDGVEVHN  AKTKPREEQY  300 NSTYRVVSVL  TVLHQDWLNG  KEYKCKVSNK
ALPAPIEKTI  SKAKGQPREP  QVYTLPPSRD  ELTKNQVSLT  CLVKGFYPSD
IAVEWESNGQ  PENNYKTTPP  VLDSDGSFFL  YSKLTVDKSR  WQQGNVFSCS
VMHEALHNHY  TQKSLSLSPG  K
(Disulfide bridge: 22-96; 148-204; 265-325; 371-429, Dimer: 230; 233)
(Light chain) DIQMTQSPSS LSASVGDRVT ITCGTSEDII NYLNWYQQKP
GKAPKLLIYH TSRLQSGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCQQ GYTLPYTFGQ
GTKVEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ
ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: 23-88; 134-194; H224-L214, Dimer)
  Type
Peptide
Class
Other
 DG02019  Interleukin inhibitor
Remark
Therapeutic category: 2290
ATC code: R03DX10
Product: D09874<JP/US>
Efficacy
Antiasthmatic, Anti-IL-5 receptor alpha antibody
  Disease
Asthma, eosinophilic phenotype [DS:H00079]
Comment
Monoclonal antibody
Target
IL5RA (CD125) [HSA:3568] [KO:K05067]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03D OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
    R03DX Other systemic drugs for obstructive airway diseases
     R03DX10 Benralizumab
      D09874  Benralizumab (USAN/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   229  Miscellaneous
    2290  Miscellaneous
     D09874  Benralizumab (USAN/INN); Benralizumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Interleukin receptors
    IL5RA (CD125)
     D09874  Benralizumab (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D09874
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09874
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09874
BRITE hierarchy
Other DBs
CAS: 1044511-01-4
PubChem: 124490602

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