KEGG   DRUG: EnokizumabHelp
Entry
D09897                      Drug                                   

Name
Enokizumab (USAN/INN)
Formula
C6496H10000N1704O2038S44
Exact mass
145895.8955
Mol weight
145985.9612
Sequence
(Heavy chain) QVQLVQSGAE VKKPGSSVKV SCKASGGTFS YYWIEWVRQA
PGQGLEWMGE ILPGSGTTNP NEKFKGRVTI TADESTSTAY MELSSLRSED TAVYYCARAD
YYGSDYVKFD YWGQGTLVTV SSASTKGPSV FPLAPSSKST SGGTAALGCL VKDYFPEPVT
VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV VTVPSSSLGT QTYICNVNHK PSNTKVDKRV
EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF
NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT
ISKAKGQPRE PQVYTLPPSR EEMTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP
PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK
(Disulfide bridge: 22-96; 149-205; 266-326; 372-430, Dimer: 231; 234)
(Light chain) DIQMTQSPSS LSASVGDRVT ITCKASQHVI THVTWYQQKP
GKAPKLLIYG TSYSYSGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCQQ FYEYPLTFGG
GTKVEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ
ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: 23-88; 134-194; H225-L214, Dimer)
  Type
Peptide
Class
Other
 DG02019  Interleukin inhibitor
Efficacy
Antiasthmatic, Anti-IL-9 antibody
Target
IL9 [HSA:3578] [KO:K05432]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway
hsa05310  Asthma
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interleukins
    IL9
     D09897  Enokizumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 909875-08-7
PubChem: 124490610

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