| Entry |
|
|---|
| Name |
Latrepirdine dihydrochloride (USAN);
Dimebolin;
Dimebon
|
|---|
| Formula |
C21H25N3. 2HCl
|
|---|
| Exact mass |
391.1582
|
|---|
| Mol weight |
392.3652
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG01498 NMDA receptor antagonist
DG01968 Agents for Alzheimer-type dementia
|
|---|
| Remark |
|
|---|
| Efficacy |
Dementia therapeutic agent, Acetylcholinesterase inhibitor, NMDA receptor antagonist |
|---|
| Comment |
Treatment of Alzheimer's disease
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07056 | Agents for Alzheimer-type dementia |
|
|---|
| Brite |
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Glutamate (ionotropic), NMDA
GRIN (NMDAR)
D09918 Latrepirdine dihydrochloride (USAN)
Enzymes
Hydrolases (EC3)
Carboxylic-ester hydrolases
ACHE
D09918 Latrepirdine dihydrochloride (USAN)
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 26
1 X Cl 30.5200 -20.5100
2 C8y C 24.2900 -24.1500
3 C8y C 25.6900 -24.1500
4 C8y C 26.1100 -22.7500
5 N4y N 24.9200 -21.9800
6 C8y C 23.8000 -22.8200
7 C8x C 26.6700 -25.1300
8 C8y C 28.0000 -24.7800
9 C8x C 28.4200 -23.4500
10 C8x C 27.4400 -22.4000
11 C1x C 22.4700 -22.6100
12 C1x C 21.5600 -23.6600
13 N1y N 22.0500 -24.9900
14 C1x C 23.3800 -25.2000
15 C1b C 24.8500 -20.5800
16 C1b C 26.1100 -19.8100
17 C8y C 26.1100 -18.4100
18 C8x C 27.3700 -17.7100
19 N5x N 27.3700 -16.3100
20 C8y C 26.1100 -15.6100
21 C8x C 24.9200 -16.3100
22 C8x C 24.9200 -17.7100
23 C1a C 26.1100 -14.2100
24 C1a C 28.9800 -25.7600
25 C1a C 21.1400 -26.0400
26 X Cl 30.5200 -20.5100
BOND 27
1 2 3 1
2 3 4 2
3 4 5 1
4 5 6 1
5 2 6 2
6 3 7 1
7 7 8 2
8 8 9 1
9 9 10 2
10 4 10 1
11 6 11 1
12 11 12 1
13 12 13 1
14 13 14 1
15 2 14 1
16 5 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 18 19 2
21 19 20 1
22 20 21 2
23 21 22 1
24 17 22 2
25 20 23 1
26 8 24 1
27 13 25 1
BRACKET 1 29.4000 -21.0700 29.4000 -19.6700
1 31.1500 -19.6700 31.1500 -21.0700
1 2
ORIGINAL 1 1
REPEAT 1 26
|
|---|
