KEGG   DRUG: Golvatinib
Entry
D10224                      Drug                                   
Name
Golvatinib (USAN)
Formula
C33H37F2N7O4
Exact mass
633.2875
Mol weight
633.6882
Structure
Simcomp
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Remark
Chemical structure group: DG01367
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
Target
MET [HSA:4233] [KO:K05099]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
  Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer
Interaction
Brite
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG01367  Golvatinib
     D10224  Golvatinib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   VEGFR family
    VEGFR2 (KDR)
     D10224  Golvatinib (USAN)
   MET family
    MET
     D10224  Golvatinib (USAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG01367  Golvatinib
Other DBs
CAS: 928037-13-2
PubChem: 163312255
ChEBI: 177746
PDB-CCD: GV0[PDBj]
KCF data

ATOM        46
            1   N1y N     4.9700  -11.3400
            2   C1x C     4.9700  -12.7400
            3   C1x C     6.1600  -13.4400
            4   N1y N     7.4200  -12.7400
            5   C1x C     7.4200  -11.3400
            6   C1x C     6.1600  -10.6400
            7   C1a C     3.7800  -10.6400
            8   C1y C     8.6100  -13.4400
            9   C1x C     8.6100  -14.8400
            10  C1x C     9.8700  -15.5400
            11  N1y N    11.0600  -14.8400
            12  C1x C    11.0600  -13.4400
            13  C1x C     9.8700  -12.7400
            14  C5a C    12.2500  -15.5400
            15  N1b N    13.4400  -14.8400
            16  O5a O    12.2500  -16.9400
            17  C8y C    14.6300  -15.5400
            18  N5x N    14.6300  -16.9400
            19  C8x C    15.8900  -17.6400
            20  C8x C    17.0800  -16.9400
            21  C8y C    17.0800  -15.5400
            22  C8x C    15.8900  -14.8400
            23  O2a O    18.2700  -14.8400
            24  C8y C    19.4600  -15.5400
            25  C8x C    19.4600  -16.9400
            26  C8y C    20.7200  -17.6400
            27  C8y C    21.9100  -16.9400
            28  C8x C    21.9100  -15.5400
            29  C8x C    20.7200  -14.8400
            30  N1b N    23.1000  -17.6400
            31  C5a C    24.2900  -16.9400
            32  C1z C    25.4800  -17.6400
            33  O5a O    24.2900  -15.5400
            34  C5a C    26.6700  -16.9400
            35  N1b N    27.8600  -17.6400
            36  O5a O    26.6700  -15.5400
            37  C8y C    29.0500  -16.9400
            38  C8x C    30.2400  -17.6400
            39  C8x C    31.5000  -16.9400
            40  C8y C    31.5000  -15.5400
            41  C8x C    30.3100  -14.8400
            42  C8x C    29.0500  -15.5400
            43  X   F    32.6900  -14.8400
            44  C1x C    24.7800  -18.8300
            45  C1x C    26.1800  -18.8300
            46  X   F    20.7372  -19.0399
BOND        51
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     4   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   11  14 1
            16   14  15 1
            17   14  16 2
            18   15  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   17  22 1
            25   21  23 1
            26   23  24 1
            27   24  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   28  29 2
            32   24  29 1
            33   27  30 1
            34   30  31 1
            35   31  32 1
            36   31  33 2
            37   32  34 1
            38   34  35 1
            39   34  36 2
            40   35  37 1
            41   37  38 2
            42   38  39 1
            43   39  40 2
            44   40  41 1
            45   41  42 2
            46   37  42 1
            47   40  43 1
            48   44  45 1
            49   45  32 1
            50   44  32 1
            51   26  46 1

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