KEGG   DRUG: Golvatinib tartrateHelp
Entry
D10465                      Drug                                   

Name
Golvatinib tartrate (USAN)
Formula
C33H37F2N7O4. C4H6O6
Exact mass
783.3039
Mol weight
783.775
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Remark
Chemical structure group: DG01367
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
Target
MET [HSA:4233] [KO:K05099]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
  Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   VEGFR family
    VEGFR2 (KDR)
     D10465  Golvatinib tartrate (USAN)
   MET family
    MET
     D10465  Golvatinib tartrate (USAN)
BRITE hierarchy
Other DBs
CAS: 1007601-96-8
PubChem: 172232558
KCF data Show

ATOM        56
            1   N1y N     7.7000  -13.9300
            2   C1x C     7.7000  -15.3300
            3   C1x C     8.8900  -16.0300
            4   N1y N    10.1500  -15.3300
            5   C1x C    10.1500  -13.9300
            6   C1x C     8.8900  -13.2300
            7   C1a C     6.5100  -13.2300
            8   C1y C    11.3400  -16.0300
            9   C1x C    11.3400  -17.4300
            10  C1x C    12.6000  -18.1300
            11  N1y N    13.7900  -17.4300
            12  C1x C    13.7900  -16.0300
            13  C1x C    12.6000  -15.3300
            14  C5a C    14.9800  -18.1300
            15  N1b N    16.1700  -17.4300
            16  O5a O    14.9800  -19.5300
            17  C8y C    17.3600  -18.1300
            18  N5x N    17.3600  -19.5300
            19  C8x C    18.6200  -20.2300
            20  C8x C    19.8100  -19.5300
            21  C8y C    19.8100  -18.1300
            22  C8x C    18.6200  -17.4300
            23  O2a O    21.0000  -17.4300
            24  C8y C    22.1900  -18.1300
            25  C8x C    22.1900  -19.5300
            26  C8y C    23.4500  -20.2300
            27  C8y C    24.6400  -19.5300
            28  C8x C    24.6400  -18.1300
            29  C8x C    23.4500  -17.4300
            30  N1b N    25.8300  -20.2300
            31  C5a C    27.0200  -19.5300
            32  C1z C    28.2100  -20.2300
            33  O5a O    27.0200  -18.1300
            34  C5a C    29.4000  -19.5300
            35  N1b N    30.6600  -20.2300
            36  O5a O    29.4000  -18.1300
            37  C8y C    31.8500  -19.5300
            38  C8x C    33.0400  -20.2300
            39  C8x C    34.3000  -19.5300
            40  C8y C    34.3000  -18.1300
            41  C8x C    33.1100  -17.4300
            42  C8x C    31.8500  -18.1300
            43  X   F    35.4900  -17.4300
            44  C1x C    27.5100  -21.4200
            45  C1x C    28.9100  -21.4200
            46  X   F    23.5200  -21.6300
            47  C1c C    22.7500  -13.9300
            48  C1c C    24.0100  -13.2300
            49  C6a C    21.5600  -13.2300
            50  O1a O    22.7500  -15.3300
            51  C6a C    25.2000  -13.9300
            52  O1a O    24.0100  -11.8300
            53  O6a O    20.3700  -13.9300
            54  O6a O    21.5600  -11.8300
            55  O6a O    26.3900  -13.2300
            56  O6a O    25.2000  -15.3300
BOND        60
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     4   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   11  14 1
            16   14  15 1
            17   14  16 2
            18   15  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   17  22 1
            25   21  23 1
            26   23  24 1
            27   24  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   28  29 2
            32   24  29 1
            33   27  30 1
            34   30  31 1
            35   31  32 1
            36   31  33 2
            37   32  34 1
            38   34  35 1
            39   34  36 2
            40   35  37 1
            41   37  38 2
            42   38  39 1
            43   39  40 2
            44   40  41 1
            45   41  42 2
            46   37  42 1
            47   40  43 1
            48   44  45 1
            49   45  32 1
            50   44  32 1
            51   26  46 1
            52   47  48 1
            53   47  49 1
            54   47  50 1 #Up
            55   48  51 1
            56   48  52 1 #Up
            57   49  53 1
            58   49  54 2
            59   51  55 1
            60   51  56 2

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