KEGG   DRUG: Emtricitabine and tenofovir alafenamide
Entry
D10835            Mixture   Drug                                   

Name
Emtricitabine and tenofovir alafenamide;
Descovy (TN)
Product
Component
Emtricitabine [DR:D01199], (Tenofovir alafenamide fumarate [DR:D10605] | Tenofovir alafenamide [DR:D10428])
Remark
Therapeutic category: 6250
ATC code: J05AR17
Product: D10835<JP/US>
Efficacy
Antiviral
  Disease
HIV infection [DS:H01563]
Comment
Tenofovir alafenamide is a substrate of cathepsin A, CYP3A and P-gp.
Target
RNA-directed DNA polymerase
Metabolism
Enzyme: CTSA [HSA:5476], CYP3A [HSA:1576 1577 1551]
Transporter: ABCB1 [HSA:5243]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AR Antivirals for treatment of HIV infections, combinations
     J05AR17 Emtricitabine and tenofoviralafenamide
      D10835  Emtricitabine and tenofovir alafenamide <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Combinations
   Emtricitabine/ Tenofovir Alafenamide Fumarate
    D10835  Emtricitabine and tenofovir alafenamide
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D10835  Emtricitabine and tenofovir alafenamide
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10835
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10835
 Drug transporters
  D10835
Other DBs
PubChem: 319902635

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Ontology (5)   
   KEGG BRITE (5)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (3)   
   KEGG DGROUP (3)   
Chemical substance (1)   
   PubChem (1)   
All databases (10)   

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