KEGG   DRUG: NeflamapimodHelp
Entry
D10959                      Drug                                   

Name
Neflamapimod (USAN)
Formula
C19H9Cl2F2N3OS
Exact mass
434.9811
Mol weight
436.2621
Structure
Mol fileKCF fileDB search
Efficacy
Anti-inflammatory, Mitogen-activated protein kinase inhibitor
Target
P38 [HSA:1432 5600 5603 6300] [KO:K04441]
  Pathway
hsa04010  MAPK signaling pathway
hsa04750  Inflammatory mediator regulation of TRP channels
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine kinases
   CMGC group
    P38
     D10959  Neflamapimod (USAN)
BRITE hierarchy
Other DBs
CAS: 209410-46-8
PubChem: 342581809
ChEMBL: CHEMBL119385
PDB-CCD: 52P[PDBj]
KCF data Show

ATOM        28
            1   C8x C    14.2100  -15.3300
            2   C8y C    14.2100  -16.7300
            3   N5x N    15.4224  -17.4300
            4   N4y N    16.6349  -16.7300
            5   C8y C    16.6349  -15.3300
            6   C8x C    15.4224  -14.6300
            7   C8x C    17.8473  -17.4300
            8   N5x N    19.0597  -16.7300
            9   C8y C    19.0597  -15.3300
            10  C8y C    17.8473  -14.6300
            11  S2a S    12.9976  -17.4300
            12  C8y C    11.8021  -16.7396
            13  C8x C    11.8020  -15.3303
            14  C8x C    10.5896  -14.6303
            15  C8y C     9.3772  -15.3303
            16  C8x C     9.3772  -16.7397
            17  C8y C    10.5896  -17.4396
            18  X   F    10.5895  -18.8299
            19  X   F     8.1667  -14.6315
            20  O5x O    20.2573  -14.6385
            21  C8y C    17.8473  -13.2300
            22  C8y C    19.0618  -12.5288
            23  C8x C    19.0618  -11.1288
            24  C8x C    17.8493  -10.4288
            25  C8x C    16.6349  -11.1300
            26  C8y C    16.6349  -12.5300
            27  X   Cl   15.4414  -13.2193
            28  X   Cl   20.2583  -13.2198
BOND        31
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 1
            11    5  10 2
            12    2  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20   17  18 1
            21   15  19 1
            22    9  20 2
            23   10  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   21  26 1
            30   26  27 1
            31   22  28 1

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