KEGG   DRUG: Piclidenoson
Entry
D10971                      Drug                                   

Name
Piclidenoson (USAN/INN)
Formula
C18H19IN6O4
Exact mass
510.0512
Mol weight
510.2857
Structure
Simcomp
Efficacy
Anti-inflammatory, Adenosine A3 receptor agonist
Comment
Treatment of dry eye, psoriasis, glaucoma, rheumatoid arthritis and osteoarthritis of the knee
Target
ADORA3 [HSA:140] [KO:K04268]
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Brite
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adenosine
    ADORA3
     D10971  Piclidenoson (USAN/INN)
Other DBs
CAS: 152918-18-8
PubChem: 342581819
ChEMBL: CHEMBL119709
KCF data

ATOM        29
            1   N4y N    18.8754  -15.3680
            2   C8y C    19.8711  -16.1990
            3   C1y C    17.5786  -15.7847
            4   C8x C    19.4773  -14.0122
            5   C8y C    21.1871  -15.4068
            6   N5x N    19.8747  -17.6311
            7   O2x O    16.4345  -14.9339
            8   C1y C    17.1503  -17.0403
            9   N5x N    20.9256  -14.1513
            10  C8y C    22.3871  -16.0712
            11  C8x C    21.1410  -18.3426
            12  C1y C    15.3314  -15.7260
            13  C1y C    15.7598  -17.0403
            14  O1a O    17.5610  -18.3780
            15  N5x N    22.4140  -17.5701
            16  N1b N    23.5665  -15.3547
            17  O1a O    15.3137  -18.3722
            18  C5a C    14.0139  -15.2945
            19  N1b N    12.7920  -15.9692
            20  O5a O    13.9715  -13.9018
            21  C1a C    11.5874  -15.2431
            22  C1b C    24.8014  -16.0317
            23  C8y C    25.9908  -15.3272
            24  C8x C    27.2033  -16.0272
            25  C8y C    28.4157  -15.3272
            26  C8x C    28.4157  -13.9272
            27  C8x C    27.2033  -13.2272
            28  C8x C    25.9908  -13.9272
            29  X   I    29.6326  -16.0298
BOND        32
            1     1   2 1
            2     3   1 1 #Up
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 2
            11    7  12 1
            12    8  13 1
            13    8  14 1 #Down
            14   10  15 2
            15   10  16 1
            16   13  17 1 #Down
            17    5   9 1
            18   11  15 1
            19   12  13 1
            20   12  18 1 #Up
            21   18  19 1
            22   18  20 2
            23   19  21 1
            24   16  22 1
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   23  28 1
            32   25  29 1

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