KEGG   DRUG: Trimethoprim hydrochloride
Entry
D11085                      Drug                                   

Name
Trimethoprim hydrochloride;
Primsol (TN);
Trimpex (TN)
Product
Formula
C14H18N4O3. HCl
Exact mass
326.1146
Mol weight
326.7787
Structure
Simcomp
Class
Antibacterial
 DG01581  Trimethoprim antibacterial
 DG01931  Dihydrofolate reductase inhibitor, antibacterial
Metabolizing enzyme inhibitor
 DG01641  CYP2C8 inhibitor
Remark
ATC code: J01EA01
Chemical structure group: DG00595
Product (DG00595): D00145<US> D11085<US>
Product (mixture): D11086<US>
Efficacy
Antibacterial, Folic acid biosynthesis inhibitor
  Disease
Uncomplicated urinary tract infections [DS:H01176]
Target
dihydrofolate reductase [KO:K13938]
  Pathway
ko00670  One carbon pool by folate
ko00790  Folate biosynthesis
Interaction
CYP inhibition: CYP2C8 [HSA:1558]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01E SULFONAMIDES AND TRIMETHOPRIM
    J01EA Trimethoprim and derivatives
     J01EA01 Trimethoprim
      D11085  Trimethoprim hydrochloride <US>
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Trimethoprim
    D11085  Trimethoprim hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11085
Other DBs
CAS: 60834-30-2
PubChem: 375581032
ChEMBL: CHEMBL1201080
KCF data

ATOM        22
            1   C8y C    18.0338  -17.1983
            2   C1b C    19.2174  -17.8945
            3   C8x C    16.8501  -17.8945
            4   C8x C    18.0338  -15.8057
            5   C8y C    20.4011  -17.1983
            6   C8y C    15.5968  -17.1983
            7   C8y C    16.8501  -15.1094
            8   C8y C    21.6544  -17.8945
            9   C8x C    20.4011  -15.7361
            10  C8y C    15.5968  -15.8057
            11  O2a O    14.4132  -17.8945
            12  O2a O    16.8501  -13.7169
            13  N5x N    22.8381  -17.1983
            14  N1a N    21.6544  -19.2871
            15  N5x N    21.6544  -15.0398
            16  O2a O    14.4132  -15.1791
            17  C1a C    13.2295  -17.1286
            18  C1a C    18.0338  -13.0206
            19  C8y C    22.8381  -15.7361
            20  C1a C    14.4132  -13.7169
            21  N1a N    24.0217  -15.0398
            22  X   Cl   26.2500  -19.1800
BOND        22
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     6  10 1
            10    6  11 1
            11    7  12 1
            12    8  13 1
            13    8  14 1
            14    9  15 2
            15   10  16 1
            16   11  17 1
            17   12  18 1
            18   13  19 2
            19   16  20 1
            20   19  21 1
            21    7  10 2
            22   15  19 1

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