KEGG   DRUG: Letolizumab
Entry
D11122                      Drug                                   
Name
Letolizumab (USAN/INN)
Formula
C1734H2688N466O538S10
Exact mass
38967.4509
Mol weight
38991.3459
Sequence
EVQLLESGGG LVQPGGSLRL SCAASGFTFN WELMGWARQA PGKGLEWVSG IEGPGDVTYY
ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCVKVG KDAKSDYRGQ GTLVTVSSAS
TEPKSSDKTH TSPPSPAPEL LGGSSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK
FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK
TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT
PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGK
(Disulfide bridge: 22-96, 167-227, 273-331)
  Type
Peptide
Efficacy
Anti-inflammatory, Anti-CD154 antibody
  Type
Monoclonal antibody
Comment
Treatment of inflammatory disease
Target
TNFSF5 (CD154) [HSA:959] [KO:K03161]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04064  NF-kappa B signaling pathway
hsa04660  T cell receptor signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Tumor necrosis factors
    TNFSF5 (CD154)
     D11122  Letolizumab (USAN/INN)
Other DBs
CAS: 1450981-87-9
PubChem: 376219046

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Ontology (1)   
   KEGG BRITE (1)   
Chemical substance (1)   
   PubChem (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (4)   

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