KEGG   DRUG: Tibulizumab
Entry
D11127                      Drug                                   

Name
Tibulizumab (USAN/INN)
Formula
C8934H13698N2398O2808S56
Exact mass
201296.715
Mol weight
201420.3777
Sequence
(Heavy chain)
QVQLQQWGAG LLKPSETLSL TCAVYGGSFS GYYWSWIRQP PGKGLEWIGE INHSGSTNYN
PSLKSRVTIS VDTSKNQFSL KLSSVTAADT AVYYCARGYY DILTGYYYYF DYWGQGTLVT
VSSASTKGPS VFPLAPCSRS TSESTAALGC LVKDYFPEPV TVSWNSGALT SGVHTFPAVL
QSSGLYSLSS VVTVPSSSLG TKTYTCNVDH KPSNTKVDKR VESKYGPPCP PCPAPEFLGG
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS QEDPEVQFNW YVDGVEVHNA KTKPREEQFN
STYRVVSVLT VLHQDWLNGK EYKCKVSNKG LPSSIEKTIS KAKGQPREPQ VYTLPPSQEE
MTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SRLTVDKSRW
QEGNVFSCSV MHEALHNHYT QKSLSLSPGG GGSGGGGTGG GGSQVQLVQS GAEVKKPGSS
VKVSCKASGY KFTDYHIHWV RQAPGQCLEW MGVINPTYGT TDYNQRFKGR VTITADESTS
TAYMELSSLR SEDTAVYYCA RYDYFTGTGV YWGQGTLVTV SSGGGGSGGG GSGGGGSGGG
GSDIVMTQTP LSLSVTPGQP ASISCRSSRS LVHSRGETYL HWYLQKPGQS PQLLIYKVSN
RFIGVPDRFS GSGSGTDFTL KISRVEAEDV GVYYCSQSTH LPFTFGCGTK LEIK
(Light chain)
EIVLTQSPAT LSLSPGERAT LSCRASQSVS RYLAWYQQKP GQAPRLLIYD ASNRATGIPA
RFSGSGSGTD STLTISSLEP EDFAVYYCQQ RSNWPRTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV 1DNALQSGNSQ ESVTEQDSKD STYSLSNTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H95, H137-L214, H150-H206, H229-H'229, H232-H'232, H264-H324, H370-H428, H485-H559, H507-H707, H625-H695, H'22-H'95, H'137-L'214, H'150-H'206, H'264-H'324, H'370-H'428, H'485-H'559, H'507-H'707, H'625-H'695, L23-L88, L134-L194, L'23-L'194)
  Type
Peptide
Efficacy
Immunomodulator
Comment
Monoclonal antibody
Treatment of autoimmune disorders
Target
TNFSF13B (BAFF, CD257) [HSA:10673] [KO:K05476]
IL17A [HSA:3605] [KO:K05489]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04064  NF-kappa B signaling pathway
hsa04657  IL-17 signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokines
   Interleukins
    IL17A
     D11127  Tibulizumab (USAN/INN)
   Tumor necrosis factors
    TNFSF13B (BAFF, CD257)
     D11127  Tibulizumab (USAN/INN)
Other DBs
CAS: 1849636-24-3
PubChem: 376219051

» Japanese version   » Back

DBGET integrated database retrieval system