KEGG   DRUG: Brontictuzumab
Entry
D11229                      Drug                                   

Name
Brontictuzumab (USAN/INN)
Formula
C6392H9862O1980N1710S50
Exact mass
143856.9615
Mol weight
143946.2177
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKI SCKVSGYTLR GYWIEWVRQA PGKGLEWIGQ ILPGTGRTNY
NEKFKGRVTM TADTSTDTAY MELSSLRSED TAVYYCARFD GNYGYYAMDY WGQGTTVTVS
SASTKGPSVF PLAPCSRSTS ESTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS
SGLYSLSSVV TVPSSNFGTQ TYTCNVDHKP SNTKVDKTVE RKCCVECPPC PAPPVAGPSV
FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVQFNWYVD GVEVHNAKTK PREEQFNSTF
RVVSVLTVVH QDWLNGKEYK CKVSNKGLPA PIEKTISKTK GQPREPQVYT LPPSREEMTK
NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPMLDS DGSFFLYSKL TVDKSRWQQG
NVFSCSVMHE ALHNHYTQKS LSLSPGK
(Light chain)
QAVVTQEPSL TVSPGGTVTL TCRSSTGAVT TSNYANWFQQ KPGQAPRTLI GGTNNRAPGV
PARFSGSLLG GKAALTLSGA QPEDEAEYYC ALWYSNHWVF GGGTKLTVLG QPKAAPSVTL
FPPSSEELQA NKATLVCLVS DFYPGAVTVA WKADGSPVKV GVETTKPSKQ SNNKYAASSY
LSLTPEQWKS HRSYSCRVTH EGSTVEKTVA PAECS
(Disulfide bridge: H22-H96, H135-L214, H148-H204, H223-H'223, H224-H'224, H227-H'227, H230-H'230, H261-H321, H367-H425, H'22-H'96, H'135-L'214, H'148-H'204, H'261-H'321, H'367-H'425, L22-L90, L137-L196, L'22-L'90, L'137-L'196)
  Type
Peptide
Efficacy
Antineoplastic
Comment
Monoclonal antibody
Target
NOTCH1 [HSA:4851] [KO:K02599]
  Pathway
hsa04330  Notch signaling pathway
hsa05200  Pathways in cancer
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Signaling molecules
   Notch signaling
    NOTCH1
     D11229  Brontictuzumab (USAN/INN)
Other DBs
CAS: 1447814-75-6
PubChem: 384585207

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