KEGG   DRUG: Bleselumab
Entry
D11357                      Drug                                   

Name
Bleselumab (USAN/INN)
Formula
C6412H9906O2018S38N1690
Exact mass
144085.3862
Mol weight
144173.8442
Sequence
(Heavy chain)
QLQLQESGPG LLKPSETLSL TCTVSGGSIS SPGYYGGWIR QPPGKGLEWI GSIYKSGSTY
HNPSLKSRVT ISVDTSKNQF SLKLSSVTAA DTAVYYCTRP VVRYFGWFDP WGQGTLVTVS
SASTKGPSVF PLAPCSRSTS ESTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS
SGLYSLSSVV TVPSSSLGTK TYTCNVDHKP SNTKVDKRVE SKYGPPCPPC PAPEFEGGPS
VFLFPPKPKD TLMISRTPEV TCVVVDVSQE DPEVQFNWYV DGVEVHNAKT KPREEQFNST
YRVVSVLTVL HQDQLNGKEY KCKVSNKGLP SSIEKTISKA KGQPREPQVY TLPPSQEEMT
KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSR LTVDKSRWQE
GNVFSCSVMH EALHNHYTQK SLSLSLGK
(Light chain)
AIQLTQSPSS LSASVGDRVT ITCRASQGIS SALAWYQQKP GKAPKLLIYD ASNLESGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ FNSYPTFGQG TKVEIKRTVA APSVFIFPPS
DEQLKSGTAS VVCLLNNFYP REAKVQWKVD NALQSGNSQE SVTEQDSKDS TYSLSSTLTL
SKADYEKHKV YACEVTHQGL SSPVTKSFNR GEC
(Disulfide bridge: H22-H97, H135-L213, H148-H204, H227-H'227, H230-H'230, H262-H322, H368-H426, H'22-H'97, H'135-L'213, H'148-H'204, H'262-H'322, H'368-H'426, L23-L88, L133-L193, L'23-L'88, L'133-L'193)
  Type
Peptide
Efficacy
Immunosuppressant, Anti-CD40 antibody
Comment
Monoclonal antibody
Preventing organ transplant rejection
Target
TNFRSF5 (CD40) [HSA:958] [KO:K03160]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04514  Cell adhesion molecules
hsa04620  Toll-like receptor signaling pathway
hsa05330  Allograft rejection
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Tumor necrosis factor receptors
    TNFRSF5 (CD40)
     D11357  Bleselumab (USAN/INN)
Other DBs
CAS: 1453067-91-8
PubChem: 384585335

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