KEGG   DRUG: Lamivudine, nevirapine and zidovudineHelp
Entry
D11521            Mixture   Drug                                   

Name
Lamivudine, nevirapine and zidovudine
Product
Component
Lamivudine [DR:D00353], Nevirapine [DR:D00435], Zidovudine [DR:D00413]
Remark
Product: D11521<US>
Efficacy
Antiviral
  Disease
HIV-1 infection [DS:H01563]
Comment
Lamivudine is a substrate of OCT2, MATE1 and MATE2-K.
Nevirapine is a substrate and an inducer of CYP3A and CYP2B6.
Zidovudine is metabolized by UDP-glucuronosyltransferase (UGT).
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551], CYP2B6 [HSA:1555], UGT [KO:K00699]
Transporter: SLC22A2 [HSA:6582], SLC47A1 [HSA:55244], SLC47A2 [HSA:146802]
Interaction
CYP induction: CYP3A [HSA:1576 1577 1551], CYP2B6 [HSA:1555]
Drug interaction
Other DBs
PubChem: 384585497

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