KEGG   DRUG: Dolutegravir and lamivudine
Entry
D11522            Mixture   Drug                                   

Name
Dolutegravir and lamivudine;
Dovato (TN)
Product
Component
(Dolutegravir sodium [DR:D10113] | Dolutegravir [DR:D10066]), Lamivudine [DR:D00353]
Remark
Therapeutic category: 6250
ATC code: J05AR25
Product: D11522<JP/US>
Efficacy
Antiviral
  Disease
HIV-1 infection [DS:H01563]
Comment
Dolutegravir is metabolized by UGT1A1 with some contribution from CYP3A; it is also an inhibitor of OCT2 and MATE1.
Target
HIV-1 integrase
RNA-directed DNA polymerase
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551], UGT1A1 [HSA:54658]
Interaction
Transporter inhibition: SLC22A2 [HSA:6582], SLC47A1 [hsa:55244]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AR Antivirals for treatment of HIV infections, combinations
     J05AR25 Lamivudine and dolutegravir
      D11522  Dolutegravir and lamivudine <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Combinations
   Dolutegravir/ Lamivudine
    D11522  Dolutegravir and lamivudine
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D11522  Dolutegravir and lamivudine
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11522
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11522
 Drug transporters
  D11522
Other DBs
PubChem: 384585498

» Japanese version   » Back

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (2)   
   KEGG DGROUP (2)   
Chemical substance (1)   
   PubChem (1)   
All databases (9)   

Download RDF
DBGET integrated database retrieval system