KEGG   DRUG: Ravagalimab
Entry
D11597                      Drug                                   

Name
Ravagalimab (USAN/INN)
Formula
C6482H10014N1734O2024S42
Exact mass
145874.2244
Mol weight
145964.002
Sequence
(Heavy chain)
EVQLVESGGG LVKPGGSLRL SCAASGFTFS DYGMNWVRQA PGKGLEWIAY ISSGRGNIYY
ADTVKGRFTI SRDNAKNSLY LQMNSLRAED TAVYYCARSW GYFDVWGQGT TVTVSSASTK
GPSVFPLAPS SKSTSGGTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP AVLQSSGLYS
LSSVVTVPSS SLGTQTYICN VNHKPSNTKV DKKVEPKSCD KTHTCPPCPA PEAAGGPSVF
LFPPKPKDQL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR
VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSREEMTKN
QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN
VFSCSVLHEA LHNHYTQKSL SLSPGK
(Light chain)
DIVMTQSPDS LAVSLGERAT INCKSSQSLL NRGNQKNYLT WFQQKPGQPP KLLIYWASTR
ESGVPDRFSG SGSGTDFTLT ISSLQAEDVA VYYCQNDYTY PLTFGQGTKL EIKRTVAAPS
VFIFPPSDEQ LKSGTASVVC LLNNFYPREA KVQWKVDNAL QSGNSQESVT EQDSKDSTYS
LSSTLTLSKA DYEKHKVYAC EVTHQGLSSP VTKSFNRGEC
(Disulfide bridge: H22-H96, H143-H199, H219-L220, H225-H'225, H228-H'228, H260-H320, H366-H424, H'22-H'96, H'143-H'199, H'219-L'220, H'260-H'320, H'366-H'424, L23-L94, L140-L200, L'23-L'94, L'140-L'200)
  Type
Peptide
Efficacy
Anti-inflammatory, Anti-CD40 antibody
Comment
Monoclonal antibody
Treatment of inflammatory and autoimmune diseases
Target
TNFRSF5 (CD40) [HSA:958] [KO:K03160]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04514  Cell adhesion molecules
hsa04620  Toll-like receptor signaling pathway
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Tumor necrosis factor receptors
    TNFRSF5 (CD40)
     D11597  Ravagalimab (USAN/INN)
Other DBs
CAS: 2050816-56-1
PubChem: 405226464

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