KEGG   DRUG: Iscalimab
Entry
D11610                      Drug                                   

Name
Iscalimab (USAN/INN)
Formula
C6470H10028N1744O2022S46
Exact mass
145980.2631
Mol weight
146070.3129
Sequence
(Heavy chain)
QVQLVESGGG VVQPGRSLRL SCAASGFTFS SYGMHWVRQA PGKGLEWVAV ISYEESNRYH
ADSVKGRFTI SRDNSKITLY LQMNSLRTED TAVYYCARDG GIAAPGPDYW GQGTLVTVSS
ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKRVEP KSCDKTHTCP PCPAPELLGG
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYA
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSREE
MTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW
QQGNVFSCSV MHEALHNHYT QKSLSLSPGK
(Light chain)
DIVMTQSPLS LTVTPGEPAS ISCRSSQSLL YSNGYNYLDW YLQKPGQSPQ VLISLGSNRA
SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCMQARQTP FTFGPGTKVD IRRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H96, H147-H203, H223-L219, H229-H'229, H232-H'232, H264-H324, H370-H428, H'22-H'96, H'147-H'203, H'223-L'219, H'264-H'324, H'370-H'428, L23-L93, L139-L199, L'23-L'93, L'139-L'199)
  Type
Peptide
Efficacy
Immunosuppressant, Anti-CD40 antibody
Comment
Monoclonal antibody
Renal transplant, Sjogren's syndrome
Target
TNFRSF5 (CD40) [HSA:958] [KO:K03160]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04514  Cell adhesion molecules
hsa04620  Toll-like receptor signaling pathway
hsa05330  Allograft rejection
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Tumor necrosis factor receptors
    TNFRSF5 (CD40)
     D11610  Iscalimab (USAN/INN)
Other DBs
CAS: 2031153-61-2
PubChem: 405226477

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