KEGG   DRUG: Infigratinib phosphateHelp
Entry
D11611                      Drug                                   

Name
Infigratinib phosphate (USAN)
Formula
C26H31Cl2N7O3. H3PO4
Exact mass
657.1634
Mol weight
658.4706
Structure
Mol fileKCF fileDB search
Remark
Chemical structure group: DG03062
Efficacy
Antineoplastic, Angiogenesis inhibitor
Target
FGFR1 (CD331) [HSA:2260] [KO:K04362]
FGFR2 (CD332) [HSA:2263] [KO:K05093]
FGFR3 (CD333) [HSA:2261] [KO:K05094]
  Pathway
hsa04010  MAPK signaling pathway
hsa05205  Proteoglycans in cancer
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   FGFR family
    FGFR1 (CD331)
     D11611  Infigratinib phosphate (USAN)
    FGFR2 (CD332)
     D11611  Infigratinib phosphate (USAN)
    FGFR3 (CD333)
     D11611  Infigratinib phosphate (USAN)
BRITE hierarchy
Other DBs
CAS: 1310746-10-1
ChEMBL: CHEMBL1834657
KCF data Show

ATOM        43
            1   N1y N     9.6102  -13.7182
            2   C1x C     9.6102  -15.1806
            3   C1x C    10.8636  -15.8769
            4   N1y N    12.0474  -15.1806
            5   C1x C    12.0474  -13.7182
            6   C1x C    10.8636  -13.0219
            7   C1b C     8.4264  -13.0219
            8   C1a C     7.2427  -13.7182
            9   C8y C    13.2312  -15.8769
            10  C8x C    13.2312  -17.2696
            11  C8x C    14.4846  -17.9659
            12  C8y C    15.6684  -17.2696
            13  C8x C    15.6684  -15.8769
            14  C8x C    14.4846  -15.1806
            15  N1b N    16.9218  -17.9659
            16  C8y C    18.1055  -17.2696
            17  C8x C    19.2893  -17.9659
            18  C8y C    20.4731  -17.2696
            19  N5x N    20.4731  -15.8073
            20  C8x C    19.2893  -15.1806
            21  N5x N    18.1055  -15.8769
            22  N1c N    21.7265  -17.9659
            23  C5a C    22.9103  -17.2696
            24  C1a C    21.7265  -19.3586
            25  N1b N    24.0941  -17.9659
            26  O5a O    22.9103  -15.8769
            27  C8y C    25.2778  -17.2696
            28  C8y C    26.4616  -17.9659
            29  C8y C    27.6454  -17.2696
            30  C8x C    27.6454  -15.8073
            31  C8y C    26.4616  -15.1806
            32  C8y C    25.2778  -15.8769
            33  X   Cl   26.4616  -19.3586
            34  O2a O    26.4616  -13.7182
            35  C1a C    27.7150  -13.0219
            36  O2a O    28.8988  -17.9659
            37  C1a C    30.0826  -17.2696
            38  X   Cl   24.0244  -15.1109
            39  P1b P    34.9300  -17.2200
            40  O1c O    34.9300  -15.8200
            41  O1c O    33.5300  -17.2200
            42  O1c O    36.3300  -17.2200
            43  O1c O    34.9300  -18.6200
BOND        45
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     4   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16   12  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   16  21 1
            24   18  22 1
            25   22  23 1
            26   22  24 1
            27   23  25 1
            28   23  26 2
            29   25  27 1
            30   27  28 2
            31   28  29 1
            32   29  30 2
            33   30  31 1
            34   31  32 2
            35   27  32 1
            36   28  33 1
            37   31  34 1
            38   34  35 1
            39   29  36 1
            40   36  37 1
            41   32  38 1
            42   39  40 2
            43   39  41 1
            44   39  42 1
            45   39  43 1

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