KEGG   DRUG: Asenapine
Entry
D11769                      Drug                                   

Name
Asenapine (INN);
Secuado (TN)
Product
  Generic
Formula
C17H16ClNO
Exact mass
285.092
Mol weight
285.768
Structure
Remark
ATC code: N05AH05
Chemical structure group: DG03100
Product (DG03100): D11769<US> D02995<JP/US>
Efficacy
Antipsychotic
  Disease
Schizophrenia [DS:H01649]
Target
HTR2A [HSA:3356] [KO:K04157]
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AH Diazepines, oxazepines and thiazepines
     N05AH05 Asenapine
      D11769  Asenapine (INN) <US>
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D11769  Asenapine (INN) <US>
   Serotonin
    HTR2A
     D11769  Asenapine (INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11769
Other DBs
CAS: 65576-45-6
PubChem: 405226635
ChEMBL: CHEMBL504548
KCF data

ATOM        20
            1   C8y C    17.7185  -15.0536
            2   C1y C    18.6245  -16.0989
            3   C1y C    20.0183  -16.0989
            4   C8y C    20.8546  -14.9839
            5   C8y C    17.9973  -13.6597
            6   C8y C    20.5061  -13.6597
            7   O2x O    19.2517  -13.0325
            8   C8x C    21.5515  -12.6841
            9   C8x C    22.8756  -13.0325
            10  C8x C    23.2241  -14.4263
            11  C8x C    22.1787  -15.4020
            12  C8x C    16.3944  -15.4717
            13  C8y C    15.3490  -14.5657
            14  C8x C    15.6278  -13.1719
            15  C8x C    16.9519  -12.7538
            16  C1x C    20.5061  -17.4231
            17  N1y N    19.3911  -18.2594
            18  C1x C    18.2063  -17.4231
            19  X   Cl   14.0249  -14.9839
            20  C1a C    19.3911  -19.6532
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     6   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    4  11 2
            13    1  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    5  15 2
            18    3  16 1
            19   16  17 1
            20   17  18 1
            21    2  18 1
            22   13  19 1
            23   17  20 1

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