KEGG   DRUG: Dextromethorphan hydrobromide and bupropion hydrochloride
Entry
D12493            Mixture   Drug                                   
Name
Dextromethorphan hydrobromide and bupropion hydrochloride;
Auvelity (TN)
Product
AUVELITY (Axsome Therapeutics)
Component
Dextromethorphan hydrobromide [DR:D00848], Bupropion hydrochloride [DR:D00817]
Class
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: N06AX62 N07XX59
Product: D12493<US>
Efficacy
Antidepressant
  Disease
Major depressive disorder [DS:H01646]
Comment
Dextromethorphan is primarily metabolized by CYP2D6.
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX62 Bupropion and dextromethorphan
      D12493  Dextromethorphan hydrobromide and bupropion hydrochloride <US>
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07X OTHER NERVOUS SYSTEM DRUGS
    N07XX Other nervous system drugs
     N07XX59 Dextromethorphan, combinations
      D12493  Dextromethorphan hydrobromide and bupropion hydrochloride <US>
USP drug classification [BR:br08302]
 Antidepressants
  Antidepressants, Other
   Dextromethorphan Hydrobromide/ Bupropion Hydrochloride
    D12493  Dextromethorphan hydrobromide and bupropion hydrochloride
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D12493  Dextromethorphan hydrobromide and bupropion hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D12493

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Ontology (4)   
   KEGG BRITE (4)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (1)   
   KEGG DGROUP (1)   
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