KEGG   DRUG: バクロフェンHelp
エントリ  
D00241                      Drug                                   

一般名   
バクロフェン (JP17);
Baclofen (JP17/USP/INN)
商品名   
米国の商品 
  後発品
BACLOFEN (Aidarex Pharmaceuticals LLC), BACLOFEN (American Health Packaging), BACLOFEN (Aphena Pharma Solutions - Tennessee), BACLOFEN (Atlantic Biologicals Corps), BACLOFEN (AvKARE), BACLOFEN (Blenheim Pharmacal), BACLOFEN (Bryant Ranch Prepack), BACLOFEN (Bryant Ranch Prepack), BACLOFEN (Bryant Ranch Prepack), BACLOFEN (Bryant Ranch Prepack), BACLOFEN (Bryant Ranch Prepack), BACLOFEN (Bryant Ranch Prepack), BACLOFEN (Cadila Healthcare Limited), BACLOFEN (Cardinal Health), BACLOFEN (DIRECT RX), BACLOFEN (DIRECT RX), BACLOFEN (Direct Rx), BACLOFEN (Dispensing Solutions), BACLOFEN (INTRATHECAL) (Emerald International Limited), BACLOFEN (H.J. Harkins Company), BACLOFEN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), BACLOFEN (Lake Erie Medical DBA Quality Care Products LLC), BACLOFEN (Lake Erie Medical DBA Quality Care Products LLC), BACLOFEN (Lake Erie Medical DBA Quality Care Products LLC), BACLOFEN (Lake Erie Medical DBA Quality Care Products LLC), BACLOFEN (Lannett Company), BACLOFEN (Major Pharmaceuticals), BACLOFEN (Major Pharmaceuticals), BACLOFEN (Marlex Pharmaceuticals), BACLOFEN (McKesson Corporation), BACLOFEN (McKesson Corporation), BACLOFEN (Med Health Pharma), BACLOFEN (Medsource Pharmaceuticals), BACLOFEN (Mylan Institutional LLC), BACLOFEN (Mylan Institutional LLC), BACLOFEN (NCS HealthCare of KY), BACLOFEN (New Horizon Rx Group), BACLOFEN (Northstar RxLLC), BACLOFEN (NuCare Pharmaceuticals), BACLOFEN (NuCare Pharmaceuticals), BACLOFEN (NuCare Pharmaceuticals), BACLOFEN (NuCare Pharmaceuticals), BACLOFEN (PD-Rx Pharmaceuticals), BACLOFEN (PD-Rx Pharmaceuticals), BACLOFEN (Par Pharmaceutical), BACLOFEN (Preferred Pharmaceuticals), BACLOFEN (Preferred Pharmaceuticals), BACLOFEN (Preferred Pharmaceuticals), BACLOFEN (Preferred Pharmaceuticals), BACLOFEN (Preferred Pharmaceuticals), BACLOFEN (Preferred Pharmaceuticals), BACLOFEN (Proficient Rx LP), BACLOFEN (Proficient Rx LP), BACLOFEN (Proficient Rx LP), BACLOFEN (REMEDYREPACK), BACLOFEN (REMEDYREPACK), BACLOFEN (REMEDYREPACK), BACLOFEN (REMEDYREPACK), BACLOFEN (REMEDYREPACK), BACLOFEN (Rebel Distributors Corp), BACLOFEN (Rebel Distributors Corp.), BACLOFEN (State of Florida DOH Central Pharmacy), BACLOFEN (Teva Pharmaceuticals USA), BACLOFEN (TruPharma LLC), BACLOFEN (Unit Dose Services), BACLOFEN (Unit Dose Services), BACLOFEN (Unit Dose Services), BACLOFEN (Upsher-Smith Laboratories), BACLOFEN (Upsher-Smith Laboratories), BACLOFEN (Zydus Pharmaceuticals (USA))
組成式   
C10H12ClNO2
質量    
213.0557
分子量   
213.6608
構造式   
Mol fileKCF fileDB search
Simcomp    SIMCOMP
クラス   
精神神経系用薬
 DG01565  GABA-B受容体作動薬
その他
 DG02029  筋弛緩薬
  DG01974  中枢性筋弛緩薬
 DG01974  中枢性筋弛緩薬
コード   
薬効分類: 1249
ATCコード: M03BX01
商品: D00241<JP/US>
効能    
鎮痙薬, 筋弛緩薬, GABA-B受容体作動薬
  疾患
脳性(小児)麻痺 [DS:H01097]
後縦靱帯骨化症 [DS:H00431]
多発性硬化症 [DS:H01490]
筋萎縮性側索硬化症 [DS:H00058]
脊髄小脳変性症 [DS:H01616]
コメント  
GABA(γ-アミノ酪酸)類似体
脊髄シナプス反射を抑制
ターゲット 
GABBR [HSA:2550 9568] [KO:K04615]
  パスウェイ
hsa04024  cAMP シグナル伝達経路
hsa04080  神経刺激性リガンドとレセプターの相互作用
hsa04727  GABA作動性シナプス
相互作用  
Drug interaction
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 1  神経系及び感覚器官用医薬品
  12  末梢神経系用薬
   124  鎮痙剤
    1249  その他の鎮痙剤
     D00241  バクロフェン (JP17)
医療用医薬品のATC分類 [BR:jp08303]
 M 筋骨格系
  M03 筋弛緩薬
   M03B 筋弛緩薬、中枢作用型薬剤
    M03BX その他の中枢作用型薬剤
     M03BX01 バクロフェン
      D00241  バクロフェン (JP17) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 抗痙性剤
  バクロフェン
   D00241  バクロフェン (JP17)
日本薬局方収載医薬品 [BR:jp08311]
 化学薬品等
  D00241  バクロフェン
  D00241  バクロフェン錠
Target-based classification of drugs  [BR:br08310]
 G Protein-coupled receptors
  Metabotropic glutamate receptor family
   GABA (metabotropic)
    GABBR
     D00241  Baclofen (JP17/USP/INN) <JP/US>
BRITE hierarchy
リンク   
CAS: 1134-47-0
PubChem: 7847307
ChEBI: 2972
ChEMBL: CHEMBL701
DrugBank: DB00181
LigandBox: D00241
日化辞: J3.661G

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