KEGG   DRUG: カルバマゼピンHelp
エントリ  
D00252                      Drug                                   

一般名   
カルバマゼピン (JP17);
Carbamazepine (JP17/USP/INN)
商品名   
  後発品
米国の商品 
  後発品
CARBAMAZEPINE (Aidarex Pharmaceuticals LLC), CARBAMAZEPINE (American Health Packaging), CARBAMAZEPINE (American Health Packaging), CARBAMAZEPINE (American Health Packaging), CARBAMAZEPINE (Aphena Pharma Solutions - Tennessee), CARBAMAZEPINE (Apotex Corp.), CARBAMAZEPINE (Apotex Corp.), CARBAMAZEPINE (Atlantic Biologicals Corps), CARBAMAZEPINE (Avera McKennan Hospital), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Cardinal Health), CARBAMAZEPINE (Clinical Solutions Wholesale), CARBAMAZEPINE (Contract Pharmacy Services-PA), CARBAMAZEPINE (Contract Pharmacy Services-PA), CARBAMAZEPINE (Contract Pharmacy Services-PA), CARBAMAZEPINE (Golden State Medical Supply), CARBAMAZEPINE (Golden State Medical Supply), CARBAMAZEPINE (Lake Erie Medical DBA Quality Care Products LLC), CARBAMAZEPINE (Major Pharmaceuticals), CARBAMAZEPINE (Morton Grove Pharmaceuticals), CARBAMAZEPINE (Mylan Institutional), CARBAMAZEPINE (NCS HealthCare of KY), CARBAMAZEPINE (NCS HealthCare of KY), CARBAMAZEPINE (Northwind Pharmaceuticals), CARBAMAZEPINE (NuCare Pharmaceuticals), CARBAMAZEPINE (NuCare Pharmaceuticals), CARBAMAZEPINE (NuCare Pharmaceuticals), CARBAMAZEPINE (PD-Rx Pharmaceuticals), CARBAMAZEPINE (Prasco Laboratories), CARBAMAZEPINE (Precision Dose), CARBAMAZEPINE (Preferred Pharmaceuticals), CARBAMAZEPINE (Preferred Pharmaceuticals), CARBAMAZEPINE (Preferred Pharmaceuticals), CARBAMAZEPINE (Proficient Rx LP), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (Rebel Distributors Corp), CARBAMAZEPINE (Sandoz), CARBAMAZEPINE (State of Florida DOH Central Pharmacy), CARBAMAZEPINE (State of Florida DOH Central Pharmacy), CARBAMAZEPINE (State of Florida DOH Central Pharmacy), CARBAMAZEPINE (TYA Pharmaceuticals), CARBAMAZEPINE (Taro Pharmaceuticals U.S.A.), CARBAMAZEPINE (Taro Pharmaceuticals U.S.A.), EPITOL (Teva Pharmaceuticals USA), CARBAMAZEPINE (Teva Pharmaceuticals USA), CARBAMAZEPINE (Torrent Pharmaceuticals Limited)
組成式   
C15H12N2O
質量    
236.095
分子量   
236.2686
構造式   
Mol fileKCF fileDB search
Simcomp    SIMCOMP
クラス   
精神神経系用薬
 DG02034  カルボキサミド系抗てんかん薬
代謝酵素基質薬
 DG02913  CYP3A4基質薬
代謝酵素誘導薬
 DG01635  CYP3A4誘導薬
トランスポーター誘導薬
 DG01893  ABCB1(P糖蛋白質)誘導薬
コード   
同一コード: C06868
薬効分類: 1139 1179
ATCコード: N03AF01
商品: D00252<JP/US>
効能    
鎮痛薬, 抗てんかん薬
  疾患
躁うつ病 [DS:H01653]
統合失調症 [DS:H01649]
コメント  
カルボキサミド誘導体
ターゲット 
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  パスウェイ
hsa04728  ドーパミン作動性シナプス
代謝    
Enzyme: CYP3A4 [HSA:1576]
相互作用  
CYP induction: CYP3A4 [HSA:1576]
Transporter induction: ABCB1 [HSA:5243]
Drug interaction
構造マップ 
map07033  抗痙攣薬
map07231  ナトリウムチャネル遮断薬
他のマップ 
map00982  薬物代謝 - チトクローム P450
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 1  神経系及び感覚器官用医薬品
  11  中枢神経系用薬
   113  抗てんかん剤
    1139  その他の抗てんかん剤
     D00252  カルバマゼピン (JP17)
   117  精神神経用剤
    1179  その他の精神神経用剤
     D00252  カルバマゼピン (JP17)
医療用医薬品のATC分類 [BR:jp08303]
 N 神経系
  N03 抗てんかん薬
   N03A 抗てんかん薬
    N03AF カルボキサミド誘導体
     N03AF01 カルバマゼピン
      D00252  カルバマゼピン (JP17) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 抗けいれん薬
  ナトリウムチャネル薬
   カルバマゼピン
    D00252  カルバマゼピン (JP17)
 双極性障害治療薬
  気分安定薬
   カルバマゼピン
    D00252  カルバマゼピン (JP17)
日本薬局方収載医薬品 [BR:jp08311]
 化学薬品等
  D00252  カルバマゼピン
Target-based classification of drugs  [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00252  Carbamazepine (JP17/USP/INN) <JP/US>
    SCN2A
     D00252  Carbamazepine (JP17/USP/INN) <JP/US>
    SCN3A
     D00252  Carbamazepine (JP17/USP/INN) <JP/US>
    SCN4A
     D00252  Carbamazepine (JP17/USP/INN) <JP/US>
    SCN5A
     D00252  Carbamazepine (JP17/USP/INN) <JP/US>
    SCN8A
     D00252  Carbamazepine (JP17/USP/INN) <JP/US>
    SCN9A
     D00252  Carbamazepine (JP17/USP/INN) <JP/US>
    SCN10A
     D00252  Carbamazepine (JP17/USP/INN) <JP/US>
    SCN11A
     D00252  Carbamazepine (JP17/USP/INN) <JP/US>
治療薬の医薬品クラス [jp08360.html]
 神経性疾患薬
  D00252
BRITE hierarchy
リンク   
CAS: 298-46-4
PubChem: 7847318
ChEBI: 3387
ChEMBL: CHEMBL108
DrugBank: DB00564
LigandBox: D00252
日化辞: J8.590A

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