KEGG   DRUG: ラモトリギンHelp
エントリ  
D00354                      Drug                                   

一般名   
ラモトリギン (JAN);
Lamotrigine (JAN/USAN/INN)
商品名   
  後発品
米国の商品 
  後発品
LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (Actavis Pharma), LAMOTRIGINE (Aidarex Pharmaceuticals LLC), LAMOTRIGINE (Aidarex Pharmaceuticals LLC), LAMOTRIGINE (Alembic Pharmaceuticals), LAMOTRIGINE (Alembic Pharmaceuticals Limited), LAMOTRIGINE (American Health Packaging), LAMOTRIGINE (Amneal Pharmaceuticals LLC), LAMOTRIGINE (Ascend Laboratories), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (AvKARE), LAMOTRIGINE (AvKARE), LAMOTRIGINE (AvPAK), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Cadila Healthcare Limited), LAMOTRIGINE (Cardinal Health), LAMOTRIGINE (Cardinal Health), LAMOTRIGINE (Carilion Materials Management), LAMOTRIGINE (Cipla USA), LAMOTRIGINE (Clinical Solutions Wholesale), LAMOTRIGINE (DIRECT RX), LAMOTRIGINE (Direct RX), LAMOTRIGINE (Dr. Reddy's Laboratories), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Glenmark Pharmaceuticals), LAMOTRIGINE (Glenmark Pharmaceuticals), LAMOTRIGINE (Golden State Medical Supply), LAMOTRIGINE (H. J. Harkins Company), LAMOTRIGINE (Hikma Pharmaceutical), LAMOTRIGINE (Impax Generics), LAMOTRIGINE (Impax Generics), LAMOTRIGINE (JUBILANT CADISTA PHARMACEUTICALS), LAMOTRIGINE (Jubilant Cadista Pharmaceuticals), LAMOTRIGINE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), LAMOTRIGINE (Lake Erie Medical DBA Quality Care Products LLC), LAMOTRIGINE (Lake Erie Medical DBA Quality Care Products LLC), LAMOTRIGINE (McKesson Corporation), LAMOTRIGINE (McKesson Corporation), LAMOTRIGINE (McKesson Corporation), LAMOTRIGINE (Mylan Institutional), LAMOTRIGINE (Mylan Pharmaceuticals), LAMOTRIGINE (NCS HealthCare of KY), LAMOTRIGINE (NCS HealthCare of KY), LAMOTRIGINE (NCS HealthCare of KY), LAMOTRIGINE (NorthStar Rx LLC), LAMOTRIGINE (NorthStar Rx LLC), LAMOTRIGINE (OWP Pharmaceuticals), SUBVENITE (OWP Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (Par Pharmaceutical), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (RPK Pharmaceuticals), LAMOTRIGINE (Rising Pharmaceuticals), LAMOTRIGINE (Sandoz), LAMOTRIGINE (ScieGen Pharmaceuticals), LAMOTRIGINE (St. Mary's Medical Park Pharmacy), LAMOTRIGINE (State of Florida DOH Central Pharmacy), LAMOTRIGINE (State of Florida DOH Central Pharmacy), LAMOTRIGINE (State of Florida DOH Central Pharmacy), LAMOTRIGINE (TYA Pharmaceuticals), LAMOTRIGINE (Taro Pharmaceuticals U.S.A.), LAMOTRIGINE (Taro Pharmaceuticals U.S.A.), LAMOTRIGINE (Teva Pharmaceuticals USA), LAMOTRIGINE (Teva Pharmaceuticals USA), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Unichem Pharmaceuticals (USA)), LAMOTRIGINE (Unit Dose Services), LAMOTRIGINE (Unit Dose Services), LAMOTRIGINE (Unit Dose Services), LAMOTRIGINE (West-ward Pharmaceutical Corp), LAMOTRIGINE (Wockhardt Limited), LAMOTRIGINE (Wockhardt USA LLC.), LAMOTRIGINE (Zydus Pharmaceuticals (USA)), LAMOTRIGINE (Alembic Pharmaceuticals), LAMOTRIGINE (Alembic Pharmaceuticals Limited), LAMOTRIGINE EXTENDED RELEASE (Bryant Ranch Prepack), LAMOTRIGINE EXTENDED RELEASE (Par Pharmaceutical), LAMOTRIGINE EXTENDED RELEASE (REMEDYREPACK), LAMOTRIGINE EXTENDED RELEASE (TruPharma)
組成式   
C9H7Cl2N5
質量    
255.0079
分子量   
256.0914
構造式   
Mol fileKCF fileDB search
クラス   
代謝酵素基質薬
 DG02924  UGT基質薬
コード   
薬効分類: 1139 1179
ATCコード: N03AX09
商品: D00354<JP/US>
効能    
双極性障害治療薬, 抗けいれん薬, 抗てんかん薬
  疾患
Lennox-Gastaut症候群 [DS:H01813]
双極性障害における気分エピソードの再発・再燃抑制 [DS:H01653]
ターゲット 
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  パスウェイ
hsa04728  ドーパミン作動性シナプス
代謝    
Enzyme: UGT1A4 [HSA:54657]
相互作用  
Drug interaction
構造マップ 
map07033  抗痙攣薬
map07231  ナトリウムチャネル遮断薬
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 1  神経系及び感覚器官用医薬品
  11  中枢神経系用薬
   113  抗てんかん剤
    1139  その他の抗てんかん剤
     D00354  ラモトリギン (JAN)
   117  精神神経用剤
    1179  その他の精神神経用剤
     D00354  ラモトリギン (JAN)
医療用医薬品のATC分類 [BR:jp08303]
 N 神経系
  N03 抗てんかん薬
   N03A 抗てんかん薬
    N03AX その他の抗てんかん薬
     N03AX09 ラモトリギン
      D00354  ラモトリギン (JAN) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 抗けいれん薬
  グルタミン酸遊離抑制薬
   ラモトリギン
    D00354  ラモトリギン (JAN)
 双極性障害治療薬
  気分安定薬
   ラモトリギン
    D00354  ラモトリギン (JAN)
Target-based classification of drugs  [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00354  Lamotrigine (JAN/USAN/INN) <JP/US>
    SCN2A
     D00354  Lamotrigine (JAN/USAN/INN) <JP/US>
    SCN3A
     D00354  Lamotrigine (JAN/USAN/INN) <JP/US>
    SCN4A
     D00354  Lamotrigine (JAN/USAN/INN) <JP/US>
    SCN5A
     D00354  Lamotrigine (JAN/USAN/INN) <JP/US>
    SCN8A
     D00354  Lamotrigine (JAN/USAN/INN) <JP/US>
    SCN9A
     D00354  Lamotrigine (JAN/USAN/INN) <JP/US>
    SCN10A
     D00354  Lamotrigine (JAN/USAN/INN) <JP/US>
    SCN11A
     D00354  Lamotrigine (JAN/USAN/INN) <JP/US>
治療薬の医薬品クラス [jp08360.html]
 神経性疾患薬
  D00354
日本の新薬 [jp08318.html]
 新有効成分含有医薬品
  D00354
BRITE hierarchy
リンク   
CAS: 84057-84-1
PubChem: 7847420
ChEBI: 6367
ChEMBL: CHEMBL741
DrugBank: DB00555
LigandBox: D00354
日化辞: J25.814H

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