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エントリ  
D00358                      Drug                                   

一般名   
リドカイン (JP17);
Lidocaine (JP17/USP/INN)
商品名   
  後発品
米国の商品 
  後発品
LIDOCAINE (Actavis Pharma), LIDOCAINE (Actavis Pharma), LIDOCAINE (Aidarex Pharmaceuticals LLC), LIDOCAINE (Aidarex Pharmaceuticals LLC), LIDOCAINE (Alembic Pharmaceuticals), LIDOCAINE (All Pharma), LIDOCAINE (All Pharma), LIDOCAINE (All Pharma), LIDOCAINE (Amneal Pharmaceuticals LLC), LIDOCAINE (Amneal Pharmaceuticals LLC), LIDOCAINE (Ascend Laboratories), LIDOCAINE (AvKARE), LIDOCAINE (AvKARE), LIDOCAINE (Bryant Ranch Prepack), LIDOCAINE (Bryant Ranch Prepack), LIDOCAINE (Cardinal Health), LIDOCAINE (Cardinal Health), LIDOCAINE (E. Fougera & Co. a division of Fougera Pharmaceuticals), LIDOCAINE (G&W Laboratories), LIDOCAINE (GSMS), LIDOCAINE (Glenmark Pharmaceuticals), LIDOCAINE (H.J. Harkins Company), LIDOCAINE (H.J. Harkins Company), LIDOCAINE (Hi-Tech Pharmacal), LIDOCAINE (IPG PHARMACEUTICALS), LIDOCAINE (IPG Pharmaceuticals), LIDOCAINE (Ingenus Pharmaceuticals), LIDOCAINE (Lake Erie Medical DBA Quality Care Products LLC), LIDOCAINE (Lake Erie Medical DBA Quality Care Products LLC), LIDOCAINE (Lake Erie Medical DBA Quality Care Products LLC), LIDOCAINE (Lake Erie Medical DBA Quality Care Products LLC), LIDOCAINE (Lake Erie Medical DBA Quality Care Products LLC), LIDOCAINE (Lake Erie Medical DBA Quality Care Products LLC), LIDOCAINE (Liberty Pharmaceuticals), LIDOCAINE (Mylan Pharmaceuticals), LIDOCAINE (Northstar Rx LLC), LIDOCAINE (Novocol), LIDOCAINE (NuCare Pharmaceuticals), LIDOCAINE (Par Pharmaceutical), LIDOCAINE (Pharmaceutica North America), LIDOCAINE (Pharmaceutica North America), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Preferred Pharmaceuticals), LIDOCAINE (Proficient Rx LP), LIDOCAINE (Proficient Rx LP), LIDOCAINE (Proficient Rx LP), LIDOCAINE (Proficient Rx LP), LIDOXRYL (PureTek Corporation), ZILACAINE PATCH (PureTek Corporation), LIDOCAINE (PureTek Corporation), LIDOPURE PATCH (PureTek Corporation), DERMACINRX LIDO V PAK (PureTek Corporation), LIDOCAINE (REMEDYREPACK), LIDOCAINE (REMEDYREPACK), LIDOCAINE (REMEDYREPACK), LIDOCAINE (Rebel Distributors Corp), LIDOCAINE (Septodont), NEURCAINE (Shoreline Pharmaceuticals), LIDOTRANS 5 PAK (Shoreline Pharmaceuticals), LIDOPAC (Sterling-Knight Pharmaceuticals), LIDOCAINE (Sterling-Knight Pharmaceuticals), LIDOCAINE (Strides Pharma Science Limited), LIDOCAINE (Taro Pharmaceuticals U.S.A.), LIDOCAINE (Taro Pharmaceuticals U.S.A.), LIDOCAINE (Teligent Pharma), LIDOCAINE (Unit Dose Services), LIDOCAINE (Unit Dose Services), LIDOCAINE (VITRUVIAS THERAPEUTICS), LIDOCAINE (medsource pharmaceuticals), LIDOCAINE (medsource pharmaceuticals), LIDOCAINE (medsource pharmaceuticals), LIDOCAINE (medsource pharmaceuticals), LIDOCAINE 5% (KBS Solutions), DERMACINRX CINLONE-II CPI (PureTek Corporation)
  その他
組成式   
C14H22N2O
質量    
234.1732
分子量   
234.3373
構造式   
Mol fileKCF fileDB search
Simcomp    SIMCOMP
クラス   
循環器系用薬
 DG01653  抗不整脈薬
  DG01652  クラスI抗不整脈薬
   DG01651  クラスIb抗不整脈薬
精神神経系用薬
 DG02030  麻酔薬
  DG01675  局所麻酔薬
   DG01673  アミド型局所麻酔薬
 DG01675  局所麻酔薬
  DG01673  アミド型局所麻酔薬
代謝酵素基質薬
 DG01892  CYP1A2基質薬
 DG02913  CYP3A4基質薬
コード   
同一コード: C07073
薬効分類: 1214
ATCコード: C01BB01 C05AD01 D04AB01 N01BB02 R02AD02 S01HA07 S02DA01
化学構造グループ: DG00196
商品 (DG00196): D00358<JP/US> D02086<JP/US> D08127<JP>
商品 (mixture): D02740<JP/US> D04881<JP> D04692<JP> D04688<JP> D07742<JP>
効能    
表面麻酔薬, 抗不整脈薬, ナトリウムチャネル遮断薬
コメント  
アニリド系
ターゲット 
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  パスウェイ
hsa04261  心筋細胞におけるアドレナリンシグナル伝達
hsa04728  ドーパミン作動性シナプス
代謝    
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576]
相互作用  
Drug interaction
構造マップ 
map07037  抗不整脈薬
map07231  ナトリウムチャネル遮断薬
他のマップ 
map00982  薬物代謝 - チトクローム P450
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 1  神経系及び感覚器官用医薬品
  12  末梢神経系用薬
   121  局所麻酔剤
    1214  キシリジン系製剤
     D00358  リドカイン (JP17)
医療用医薬品のATC分類 [BR:jp08303]
 C 循環器系
  C01 心疾患治療
   C01B 抗不整脈薬、クラスIとIII
    C01BB 抗不整脈薬、クラスIb
     C01BB01 リドカイン
      D00358  リドカイン (JP17) <JP/US>
  C05 血管保護薬
   C05A 痔核と裂肛の局所用治療薬
    C05AD 局所麻酔薬
     C05AD01 リドカイン
      D00358  リドカイン (JP17) <JP/US>
 D 皮膚科用薬
  D04 鎮痒薬、抗ヒスタミン薬・麻酔薬等を含む
   D04A 鎮痒薬、抗ヒスタミン薬・麻酔薬等を含む
    D04AB 全身用麻酔薬
     D04AB01 リドカイン
      D00358  リドカイン (JP17) <JP/US>
 N 神経系
  N01 麻酔薬
   N01B 麻酔薬、局所
    N01BB アミド
     N01BB02 リドカイン
      D00358  リドカイン (JP17) <JP/US>
 R 呼吸器系
  R02 咽頭用製剤
   R02A 咽頭用製剤
    R02AD 麻酔薬、局所
     R02AD02 リドカイン
      D00358  リドカイン (JP17) <JP/US>
 S 感覚器
  S01 眼科用薬
   S01H 局所麻酔薬
    S01HA 局所麻酔薬
     S01HA07 リドカイン
      D00358  リドカイン (JP17) <JP/US>
  S02 耳科用薬
   S02D その他の耳科用薬
    S02DA 鎮痛薬と麻酔薬
     S02DA01 リドカイン
      D00358  リドカイン (JP17) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 麻酔薬
  局所麻酔薬
   リドカイン
    D00358  リドカイン (JP17)
一般用医薬品の分類 [BR:jp08313]
 泌尿生殖器官及び肛門用薬
  30 外用痔疾用薬
   D00358  リドカイン (JP17)
 外皮用薬
  57 鎮痛・鎮痒・収れん・消炎薬(パップ剤を含む)
   D00358  リドカイン (JP17)
一般用医薬品のリスク区分 [BR:jp08312]
 第二類
  無機薬品及び有機薬品
   リドカイン
    D00358  リドカイン (JP17)
医薬品添加物 [BR:jp08316]
 無痛化剤
  D00358  [001667] リドカイン
 溶解剤
  D00358  [001667] リドカイン
 溶解補助剤
  D00358  [001667] リドカイン
 溶剤
  D00358  [001667] リドカイン
日本薬局方収載医薬品 [BR:jp08311]
 化学薬品等
  D00358  リドカイン
  D00358  リドカイン注射液
Target-based classification of drugs  [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00358  Lidocaine (JP17/USP/INN) <JP/US>
    SCN2A
     D00358  Lidocaine (JP17/USP/INN) <JP/US>
    SCN3A
     D00358  Lidocaine (JP17/USP/INN) <JP/US>
    SCN4A
     D00358  Lidocaine (JP17/USP/INN) <JP/US>
    SCN5A
     D00358  Lidocaine (JP17/USP/INN) <JP/US>
    SCN8A
     D00358  Lidocaine (JP17/USP/INN) <JP/US>
    SCN9A
     D00358  Lidocaine (JP17/USP/INN) <JP/US>
    SCN10A
     D00358  Lidocaine (JP17/USP/INN) <JP/US>
    SCN11A
     D00358  Lidocaine (JP17/USP/INN) <JP/US>
治療薬の医薬品クラス [jp08360.html]
 麻酔薬・鎮痛薬と抗炎症薬
  D00358
BRITE hierarchy
リンク   
CAS: 137-58-6
PubChem: 7847424
ChEBI: 6456
ChEMBL: CHEMBL79
DrugBank: DB00281
PDB-CCD: LQZ[PDBj]
LigandBox: D00358
日化辞: J5.631F

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