KEGG   DRUG: シンバスタチンHelp
エントリ  
D00434                      Drug                                   

一般名   
シンバスタチン (JP17);
Simvastatin (JP17/USP/INN);
MK-733
商品名   
  後発品
シンバスタチン (あすか製薬), シンバスタチン (あすか製薬), シンバスタチン (キョーリンリメディオ), シンバスタチン (キョーリンリメディオ), シンバスタチン (キョーリンリメディオ), シンバスタチン (サンノーバ), シンバスタチン (サンノーバ), シンバスタチン (マイラン製薬), シンバスタチン (メディサ新薬), シンバスタチン (メディサ新薬), シンバスタチン (共和薬品工業), シンバスタチン (大原薬品工業), シンバスタチン (大原薬品工業), シンバスタチン (大原薬品工業), シンバスタチン (小林化工), シンバスタチン (日医工), シンバスタチン (日医工ファーマ), シンバスタチン (東和薬品), シンバスタチン (武田テバファーマ), シンバスタチン (沢井製薬), シンバスタチン (陽進堂), シンバスタチン (陽進堂), シンバスタチン (陽進堂), ラミアン (あすか製薬), ラミアン (あすか製薬), リポザート (武田テバファーマ)
Similar product
米国の商品 
  後発品
SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (A-S Medication Solutions), SIMVASTATIN (ACETRIS HEALTH), SIMVASTATIN (Accord Healthcare), SIMVASTATIN (Aidarex Pharmaceuticals LLC), SIMVASTATIN (Aidarex Pharmaceuticals LLC), SIMVASTATIN (American Health Packaging), SIMVASTATIN (American Health Packaging), SIMVASTATIN (Aphena Pharma Solutions - Tennessee), SIMVASTATIN (Aphena Pharma Solutions - Tennessee), SIMVASTATIN (Aphena Pharma Solutions - Tennessee), SIMVASTATIN (Aphena Pharma Solutions - Tennessee), SIMVASTATIN (Aphena Pharma Solutions - Tennessee), SIMVASTATIN (Aphena Pharma Solutions - Tennessee), SIMVASTATIN (Aphena Pharma Solutions - Tennessee), SIMVASTATIN (Aurobindo Pharma Limited), SIMVASTATIN (Aurolife Pharma LLC), SIMVASTATIN (AvPAK), SIMVASTATIN (Biocon Limited), SIMVASTATIN (Biocon Pharma Inc,), SIMVASTATIN (Blenheim Pharmacal), SIMVASTATIN (Blenheim Pharmacal), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Bryant Ranch Prepack), SIMVASTATIN (Cadila Healthcare Limited), SIMVASTATIN (Camber Pharmaceuticals), SIMVASTATIN (Cardinal Health), SIMVASTATIN (Cardinal Health), SIMVASTATIN (Carilion Materials Management), SIMVASTATIN (Contract Pharmacy Services-PA), SIMVASTATIN (Contract Pharmacy Services-PA), SIMVASTATIN (Contract Pharmacy Services-PA), SIMVASTATIN (DIRECT RX), SIMVASTATIN (DOH CENTRAL PHARMACY), SIMVASTATIN (Direct Rx), SIMVASTATIN (Direct_Rx), SIMVASTATIN (Dr. Reddy's Laboratories Limited), SIMVASTATIN (H.J. Harkins Company), SIMVASTATIN (H.J. 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組成式   
C25H38O5
質量    
418.2719
分子量   
418.5662
構造式   
Mol fileKCF fileDB search
Simcomp    SIMCOMP
クラス   
循環器系用薬
 DG01660  HMG-CoA還元酵素阻害薬
 DG01946  脂質異常症治療薬
  DG01660  HMG-CoA還元酵素阻害薬
代謝酵素基質薬
 DG02913  CYP3A4基質薬
トランスポーター基質薬
 DG02856  SLCO1B1(OATP1B1)基質薬
コード   
薬効分類: 2189
ATCコード: C10AA01
商品: D00434<JP/US>
商品 (mixture): D10257<US>
効能    
脂質異常症治療薬, HMG-CoA還元酵素阻害薬
  疾患
高脂血症 [DS:H01635]
家族性高コレステロール血症 [DS:H00155]
コメント  
プロドラッグ活性体: シンバスタチン酸 [CPD:C21581]
ターゲット 
HMGCR [HSA:3156] [KO:K00021]
  パスウェイ
hsa00900  テルペノイド骨格の生合成
代謝    
Enzyme: CYP3A4 [HSA:1576]
Transporter: SLCO1B1 [HSA:10599]
相互作用  
Drug interaction
構造マップ 
map07024  HMG-CoA 還元酵素阻害薬
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 2  個々の器官系用医薬品
  21  循環器官用薬
   218  高脂血症用剤
    2189  その他の高脂血症用剤
     D00434  シンバスタチン (JP17)
医療用医薬品のATC分類 [BR:jp08303]
 C 循環器系
  C10 脂質修飾剤
   C10A 脂質修飾剤、単剤
    C10AA HMG-CoA 還元酵素阻害薬
     C10AA01 シンバスタチン
      D00434  シンバスタチン (JP17) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 心血管治療薬
  異脂肪血症治療薬, ヒドロキシメチルグルタリルコエンザイムA還元酵素阻害薬
   シンバスタチン
    D00434  シンバスタチン (JP17)
日本薬局方収載医薬品 [BR:jp08311]
 化学薬品等
  D00434  シンバスタチン
  D00434  シンバスタチン錠
Target-based classification of drugs  [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    HMGCR
     D00434  Simvastatin (JP17/USP/INN) <JP/US>
治療薬の医薬品クラス [jp08360.html]
 脂質異常症治療薬
  D00434
BRITE hierarchy
リンク   
CAS: 79902-63-9
PubChem: 7847500
ChEBI: 9150
ChEMBL: CHEMBL1064 CHEMBL3349544
DrugBank: DB00641
LigandBox: D00434
日化辞: J152.218C

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