KEGG   DRUG: スピロノラクトンHelp
エントリ  
D00443                      Drug                                   

一般名   
スピロノラクトン (JP17);
Spironolactone (JP17/USP/INN)
商品名   
  後発品
米国の商品 
  後発品
SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (A-S Medication Solutions), SPIRONOLACTONE (Accord Healthcare), SPIRONOLACTONE (Actavis Pharma), SPIRONOLACTONE (Aidarex Pharmaceuticals LLC), SPIRONOLACTONE (Aidarex Pharmaceuticals LLC), SPIRONOLACTONE (Aidarex Pharmaceuticals LLC), SPIRONOLACTONE (American Health Packaging), SPIRONOLACTONE (Amneal Pharmaceuticals LLC), SPIRONOLACTONE (Amneal Pharmaceuticals of New York LLC), SPIRONOLACTONE (Aphena Pharma Solutions - Tennessee), SPIRONOLACTONE (Aphena Pharma Solutions - Tennessee), SPIRONOLACTONE (Aphena Pharma Solutions - Tennessee), SPIRONOLACTONE (AvPAK), SPIRONOLACTONE (Blenheim Pharmacal), SPIRONOLACTONE (Blenheim Pharmacal), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Bryant Ranch Prepack), SPIRONOLACTONE (Cadila Healthcare Limited), SPIRONOLACTONE (Cardinal Health), SPIRONOLACTONE (Cardinal Health), SPIRONOLACTONE (Carilion Materials Management), SPIRONOLACTONE (Contract Pharmacy Services-PA), SPIRONOLACTONE (Dispensing Solutions), SPIRONOLACTONE (Greenstone LLC), SPIRONOLACTONE (Jubilant Cadista Pharmaceuticals), SPIRONOLACTONE (Lake Erie Medical DBA Quality Care Products LLC), SPIRONOLACTONE (Lake Erie Medical DBA Quality Care Products LLC), SPIRONOLACTONE (Lake Erie Medical DBA Quality Care Products LLC), SPIRONOLACTONE (Major Pharmaceuticals), SPIRONOLACTONE (McKesson Corporation), SPIRONOLACTONE (McKesson Corporation dba SKY Packaging), SPIRONOLACTONE (Mylan Institutional), SPIRONOLACTONE (Mylan Pharmaceuticals), SPIRONOLACTONE (NCS HealthCare of KY), SPIRONOLACTONE (NCS HealthCare of KY), SPIRONOLACTONE (NCS HealthCare of KY), SPIRONOLACTONE (NCS HealthCare of KY), SPIRONOLACTONE (Northwind Pharmaceuticals), SPIRONOLACTONE (NuCare Pharmaceuticals), SPIRONOLACTONE (NuCare Pharmaceuticals), SPIRONOLACTONE (NuCare Pharmaceuticals), SPIRONOLACTONE (NuCare Pharmaceuticals), SPIRONOLACTONE (NuCare Pharmaceuticals), SPIRONOLACTONE (NuCare Pharmaceuticals), SPIRONOLACTONE (PD-Rx Pharmaceuticals), SPIRONOLACTONE (PD-Rx Pharmaceuticals), SPIRONOLACTONE (PD-Rx Pharmaceuticals), SPIRONOLACTONE (Par Pharmaceutical), SPIRONOLACTONE (Preferred Pharmaceuticals), SPIRONOLACTONE (Preferred Pharmaceuticals), SPIRONOLACTONE (Preferred Pharmaceuticals), SPIRONOLACTONE (Preferred Pharmaceuticals), SPIRONOLACTONE (Preferred Pharmaceuticals), SPIRONOLACTONE (Preferred Pharmaceuticals), SPIRONOLACTONE (Preferred Pharmaceuticals), SPIRONOLACTONE (Preferred Pharmaceuticals), SPIRONOLACTONE (Proficient Rx LP), SPIRONOLACTONE (Proficient Rx LP), SPIRONOLACTONE (Proficient Rx LP), SPIRONOLACTONE (Proficient Rx LP), SPIRONOLACTONE (QPharma), SPIRONOLACTONE (Quality Care Products), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (REMEDYREPACK), SPIRONOLACTONE (RPK Pharmaceuticals), SPIRONOLACTONE (Rebel Distributors Corp), SPIRONOLACTONE (Rebel Distributors Corp), SPIRONOLACTONE (Rebel Distributors Corp), SPIRONOLACTONE (RedPharm Drug), SPIRONOLACTONE (Sandoz), SPIRONOLACTONE (St. Mary's Medical Park Pharmacy), SPIRONOLACTONE (State of Florida DOH Central Pharmacy), SPIRONOLACTONE (State of Florida DOH Central Pharmacy), SPIRONOLACTONE (State of Florida DOH Central Pharmacy), SPIRONOLACTONE (Sun Pharmaceutical Industries), SPIRONOLACTONE (Unit Dose Services), SPIRONOLACTONE (Unit Dose Services), SPIRONOLACTONE (Unit Dose Services), SPIRONOLACTONE (Zydus Pharmaceuticals (USA))
組成式   
C24H32O4S
質量    
416.2021
分子量   
416.5735
構造式   
Mol fileKCF fileDB search
Simcomp    SIMCOMP
クラス   
循環器系用薬
 DG01885  カリウム保持性利尿薬
  DG01676  アルドステロン拮抗薬
コード   
同一コード: C07310
薬効分類: 2133
ATCコード: C03DA01
商品: D00443<JP/US>
商品 (mixture): D10270<US>
効能    
血圧降下薬, 利尿薬, アルドステロン拮抗薬
  疾患
高血圧症 [DS:H01633]
原発性アルドステロン症 [DS:H01603]
ターゲット 
NR3C2 (MR) [HSA:4306] [KO:K08555]
  パスウェイ
hsa04960  アルドステロンの調節によるナトリウムの再吸収
相互作用  
Drug interaction
構造マップ 
map07225  糖質コルチコイド・鉱質コルチコイド受容体の作動薬と拮抗薬
階層分類  
医療用医薬品の薬効分類 [BR:jp08301]
 2  個々の器官系用医薬品
  21  循環器官用薬
   213  利尿剤
    2133  抗アルドステロン製剤;トリアムテレン等
     D00443  スピロノラクトン (JP17)
医療用医薬品のATC分類 [BR:jp08303]
 C 循環器系
  C03 利尿薬
   C03D カリウム保持剤
    C03DA アルドステロン拮抗薬
     C03DA01 スピロノラクトン
      D00443  スピロノラクトン (JP17) <JP/US>
医療用医薬品のUSP分類 [BR:jp08302]
 心血管治療薬
  カリウム保持性利尿薬
   スピロノラクトン
    D00443  スピロノラクトン (JP17)
日本薬局方収載医薬品 [BR:jp08311]
 化学薬品等
  D00443  スピロノラクトン
  D00443  スピロノラクトン錠
Target-based classification of drugs  [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C2 (MR)
     D00443  Spironolactone (JP17/USP/INN) <JP/US>
治療薬の医薬品クラス [jp08360.html]
 循環器用薬
  D00443
 内分泌・ホルモン関連薬
  D00443
BRITE hierarchy
リンク   
CAS: 52-01-7
PubChem: 7847509
ChEBI: 9241
ChEMBL: CHEMBL1320310 CHEMBL1393 CHEMBL1473269
DrugBank: DB00421
PDB-CCD: SNL[PDBj]
LigandBox: D00443
日化辞: J4.474A

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