KEGG   PATHWAY: dro04514
dro04514                    Pathway                                

Cell adhesion molecules - Desmodus rotundus (common vampire bat)
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Environmental Information Processing; Signaling molecules and interaction
Pathway map
dro04514  Cell adhesion molecules

Other DBs
GO: 0050839
Desmodus rotundus (common vampire bat) [GN:dro]
112314034  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
112314019  CD2; T-cell surface antigen CD2 [KO:K06449]
112305474  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
112320471  IGSF11; immunoglobulin superfamily member 11 [KO:K06791]
112320475  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
112302711  CD274; programmed cell death 1 ligand 1 [KO:K06745]
112307972  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
112320646  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
112307993  CTLA4; cytotoxic T-lymphocyte protein 4 isoform X1 [KO:K06538]
112304330  ICOSLG; ICOS ligand isoform X1 [KO:K06710]
112307652  ICOS; inducible T-cell costimulator [KO:K06713]
112302159  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
112302160  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
112302240  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
112302328  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
112302354  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
112322003  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
112297492  RLA class I histocompatibility antigen, alpha chain 11/11-like [KO:K06751]
112313872  patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
112313873  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
112313875  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112313876  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
112313879  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-39 alpha chain-like [KO:K06751]
112313880  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
112314045  HLA class I histocompatibility antigen, A-36 alpha chain-like isoform X1 [KO:K06751]
112314059  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
112314061  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
112314062  HLA class I histocompatibility antigen, B-48 alpha chain-like [KO:K06751]
112314063  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112314064  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112302342  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112302447  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
112302469  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112302983  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
112302981  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
112302897  PDCD1LG2; programmed cell death 1 ligand 2 [KO:K06708]
112301892  CD276; CD276 antigen isoform X1 [KO:K06746]
112313993  VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
112308039  PDCD1; programmed cell death protein 1 [KO:K06744]
112304112  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
112307303  CD40LG; CD40 ligand isoform X1 [KO:K03161]
112320404  ALCAM; CD166 antigen isoform X1 [KO:K06547]
112317206  CD6; T-cell differentiation antigen CD6 [KO:K06456]
112312859  PVR; poliovirus receptor [KO:K06539]
112322850  CD226; LOW QUALITY PROTEIN: CD226 antigen [KO:K06567]
112312912  NECTIN2; nectin-2 isoform X1 [KO:K06531]
112320511  TIGIT; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
112304654  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
112304402  ITGB2; integrin beta-2 [KO:K06464]
112301541  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
112316333  ICAM2; intercellular adhesion molecule 2 [KO:K06523]
112301532  ICAM3; LOW QUALITY PROTEIN: intercellular adhesion molecule 3 [KO:K06486]
112320238  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
112318902  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:]
112303962  SIGLEC1; sialoadhesin [KO:K06548]
112304851  SPN; leukosialin [KO:K06477]
112320462  NECTIN3; nectin-3 [KO:K06592]
112313306  CLDN34; claudin-34 [KO:K06087]
112304835  CLDN11; claudin-11 [KO:K06087]
112314173  CLDN25; putative claudin-25 [KO:K06087]
112304019  CLDN17; claudin-17 [KO:K06087]
112304029  CLDN8; claudin-8 [KO:K06087]
112306681  CLDN23; LOW QUALITY PROTEIN: claudin-23 [KO:K06087]
112297137  CLDN20; claudin-20 [KO:K06087]
112315055  CLDN15; claudin-15 [KO:K06087]
112309977  CLDN18; claudin-18 isoform X1 [KO:K06087]
112301928  CLDN5; claudin-5 [KO:K06087]
112308639  CLDN7; claudin-7 [KO:K06087]
112296885  CLDN2; claudin-2 [KO:K06087]
112314877  CLDN3; claudin-3 [KO:K06087]
112314881  CLDN4; claudin-4 [KO:K06087]
112312321  CLDN10; claudin-10 isoform X1 [KO:K06087]
112298480  CLDN6; claudin-6 [KO:K06087]
112298481  CLDN9; claudin-9 [KO:K06087]
112299540  CLDN19; claudin-19 [KO:K06087]
112300910  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
112300966  CLDN1; claudin-1 [KO:K06087]
112304110  CLDN14; claudin-14 [KO:K06087]
112306760  CLDN22; claudin-22 [KO:K06087]
112306761  putative claudin-24 [KO:K06087]
112321073  OCLN; occludin isoform X1 [KO:K06088]
112322961  F11R; junctional adhesion molecule A [KO:K06089]
112304482  JAM2; junctional adhesion molecule B [KO:K06735]
112301929  JAM3; junctional adhesion molecule C [KO:K06785]
112301890  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
112300671  CDH5; cadherin-5 [KO:K06533]
112316264  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
112313323  CD99; CD99 antigen isoform X1 [KO:K06520]
112296320  CD99L2; CD99 antigen-like protein 2 isoform X1 [KO:K06520]
112304783  ITGAM; integrin alpha-M [KO:K06461]
112310748  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
112321423  SELP; LOW QUALITY PROTEIN: P-selectin [KO:K06496]
112305817  ITGA4; integrin alpha-4 [KO:K06483]
112317701  ITGB1; integrin beta-1 [KO:K05719]
112309728  ITGA9; integrin alpha-9 [KO:K06585]
112314077  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
112318624  ITGB7; integrin beta-7 [KO:K06590]
112312295  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
112321343  SELL; L-selectin [KO:K06495]
112318439  CD34; hematopoietic progenitor cell antigen CD34 [KO:K06474]
112300752  GLG1; Golgi apparatus protein 1 [KO:K06816]
112312974  NECTIN1; nectin-1 [KO:K06081]
112322711  CDH2; cadherin-2 [KO:K06736]
112314344  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
112306731  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
112296327  L1CAM; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
112314332  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
112309277  NEGR1; neuronal growth regulator 1 isoform X1 [KO:K06775]
112314040  NTNG1; netrin-G1 [KO:K07522]
112303364  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
112306551  NTNG2; netrin-G2 [KO:K16359]
112299730  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
112314628  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:]
112310098  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
112297736  SDC1; syndecan-1 isoform X1 [KO:K06257]
112315472  SDC2; syndecan-2 [KO:K16336]
112299292  SDC3; syndecan-3 [KO:K16337]
112303758  SDC4; syndecan-4 [KO:K16338]
112305765  ITGAV; integrin alpha-V [KO:K06487]
112306853  ITGB8; integrin beta-8 [KO:K06591]
112320534  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
112297925  NRXN1; neurexin-1 isoform X1 [KO:K07377]
112311540  NRXN3; neurexin 3 isoform X1 [KO:K07377]
112317388  NRXN2; LOW QUALITY PROTEIN: neurexin-2-beta [KO:K07377]
112300045  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
112308592  NLGN2; neuroligin-2 [KO:K07378]
112304942  NLGN1; neuroligin-1 isoform X1 [KO:K07378]
112313310  NLGN4X; neuroligin-4, X-linked [KO:K07378]
112317651  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
112302888  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
112318451  CNTN1; contactin-1 isoform X1 [KO:K06759]
112322734  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:]
112314909  CNTN2; contactin-2 [KO:K06760]
112314887  NFASC; neurofascin isoform X1 [KO:K06757]
112298571  CNTNAP1; contactin-associated protein 1 [KO:K07379]
112308294  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
112297225  MPZ; myelin protein P0 isoform X1 [KO:K06770]
112298716  MPZL1; myelin protein zero-like protein 1 isoform X1 [KO:K06770]
112320108  MAG; myelin-associated glycoprotein isoform X1 [KO:K06771]
112300798  CDH1; cadherin-1 [KO:K05689]
112307555  VCAN; versican core protein isoform X1 [KO:K06793]
112305805  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
112300634  CDH3; cadherin-3 isoform X1 [KO:K06796]
112303885  CDH4; cadherin-4 [KO:K06797]
112300570  CDH15; cadherin-15 [KO:K06809]
112301682  NEO1; neogenin [KO:K06766]
Barclay AN.
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
Semin Immunol 15:215-23 (2003)
Sharpe AH, Freeman GJ.
The B7-CD28 superfamily.
Nat Rev Immunol 2:116-26 (2002)
Grewal IS, Flavell RA.
CD40 and CD154 in cell-mediated immunity.
Annu Rev Immunol 16:111-35 (1998)
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
J Immunol 175:1558-65 (2005)
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
Cell adhesion and polarity during immune interactions.
Immunol Rev 186:68-82 (2002)
Dejana E.
Endothelial cell-cell junctions: happy together.
Nat Rev Mol Cell Biol 5:261-70 (2004)
Bazzoni G.
The JAM family of junctional adhesion molecules.
Curr Opin Cell Biol 15:525-30 (2003)
Becker BF, Heindl B, Kupatt C, Zahler S.
Endothelial function and hemostasis.
Z Kardiol 89:160-7 (2000)
Elangbam CS, Qualls CW Jr, Dahlgren RR.
Cell adhesion molecules--update.
Vet Pathol 34:61-73 (1997)
Muller WA.
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
Trends Immunol 24:327-34 (2003)
Yamagata M, Sanes JR, Weiner JA.
Synaptic adhesion molecules.
Curr Opin Cell Biol 15:621-32 (2003)
Ethell IM, Pasquale EB.
Molecular mechanisms of dendritic spine development and remodeling.
Prog Neurobiol 75:161-205 (2005)
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
Making memories stick: cell-adhesion molecules in synaptic plasticity.
Trends Cell Biol 10:473-82 (2000)
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
Mol Cell Neurosci 19:292-306 (2002)
Dunican DJ, Doherty P.
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
Mol Cell Biol Res Commun 3:255-63 (2000)
Girault JA, Peles E.
Development of nodes of Ranvier.
Curr Opin Neurobiol 12:476-85 (2002)
Arroyo EJ, Scherer SS.
On the molecular architecture of myelinated fibers.
Histochem Cell Biol 113:1-18 (2000)
Salzer JL.
Polarized domains of myelinated axons.
Neuron 40:297-318 (2003)
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
Roles and modes of action of nectins in cell-cell adhesion.
Semin Cell Dev Biol 15:643-56 (2004)
Nakanishi H, Takai Y.
Roles of nectins in cell adhesion, migration and polarization.
Biol Chem 385:885-92 (2004)
Siu MK, Cheng CY.
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
Biol Reprod 71:375-91 (2004)
Lee NP, Cheng CY.
Adaptors, junction dynamics, and spermatogenesis.
Biol Reprod 71:392-404 (2004)
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
Development 132:1525-37 (2005)
Marthiens V, Gavard J, Lambert M, Mege RM.
Cadherin-based cell adhesion in neuromuscular development.
Biol Cell 94:315-26 (2002)
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
J Cell Sci 118:2355-62 (2005)
dro04520  Adherens junction
dro04530  Tight junction
dro04610  Complement and coagulation cascades
dro04660  T cell receptor signaling pathway
dro04670  Leukocyte transendothelial migration
KO pathway

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