KEGG   PATHWAY: dro04612
Entry
dro04612                    Pathway                                

Name
Antigen processing and presentation - Desmodus rotundus (common vampire bat)
Class
Organismal Systems; Immune system
Pathway map
dro04612  Antigen processing and presentation
dro04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112319176  IFNG; interferon gamma [KO:K04687]
112302067  TNF; tumor necrosis factor isoform X1 [KO:K03156]
112300654  PSME1; proteasome activator complex subunit 1 [KO:K06696]
112300637  PSME2; proteasome activator complex subunit 2 isoform X1 [KO:K06697]
112301167  LOW QUALITY PROTEIN: proteasome activator complex subunit 2-like [KO:K06697]
112298579  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
112301823  HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
112311414  HSPA2; heat shock-related 70 kDa protein 2 [KO:K03283]
112302142  heat shock 70 kDa protein 1 [KO:K03283]
112302152  heat shock 70 kDa protein 1-like [KO:K03283]
112318080  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
112311492  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
112302203  HSP90AB1; LOW QUALITY PROTEIN: heat shock protein HSP 90-beta [KO:K04079]
112297492  RLA class I histocompatibility antigen, alpha chain 11/11-like [KO:K06751]
112313872  patr class I histocompatibility antigen, alpha chain E-like [KO:K06751]
112313873  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
112313875  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112313876  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
112313879  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-39 alpha chain-like [KO:K06751]
112313880  HLA class I histocompatibility antigen, B-15 alpha chain-like [KO:K06751]
112314045  HLA class I histocompatibility antigen, A-36 alpha chain-like isoform X1 [KO:K06751]
112314059  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
112314061  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
112314062  HLA class I histocompatibility antigen, B-48 alpha chain-like [KO:K06751]
112314063  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112314064  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112302342  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112302447  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
112302469  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
112306383  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
112296374  CANX; calnexin [KO:K08054]
112311727  B2M; beta-2-microglobulin [KO:K08055]
112311189  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
112301566  CALR; calreticulin [KO:K08057]
112302089  TAPBP; tapasin isoform X1 [KO:K08058]
112302332  TAP1; antigen peptide transporter 1 isoform X1 [KO:K05653]
112302216  TAP2; antigen peptide transporter 2 [KO:K05654]
112302983  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
112302981  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
112313840  LOW QUALITY PROTEIN: killer cell immunoglobulin-like receptor 3DL3 [KO:K07980]
112321816  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
112318526  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
112307057  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
112321952  natural killer cells antigen CD94-like [KO:K06516]
112321959  natural killer cells antigen CD94-like [KO:K06516]
112305211  IFI30; gamma-interferon-inducible lysosomal thiol reductase [KO:K08059]
112311858  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
112312250  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
112302159  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
112302160  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
112302240  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
112302328  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
112302354  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
112319701  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
112302733  CTSV; LOW QUALITY PROTEIN: cathepsin L2 [KO:K01365] [EC:3.4.22.15]
112302874  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
112313687  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
112322003  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
112314942  CIITA; MHC class II transactivator [KO:K08060] [EC:2.7.11.1]
112313958  RFX5; DNA-binding protein RFX5 [KO:K08061]
112305217  RFXANK; DNA-binding protein RFXANK [KO:K08062]
112313590  RFXAP; regulatory factor X-associated protein [KO:K08063]
112307981  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
112302352  NFYA; nuclear transcription factor Y subunit alpha [KO:K08064]
112321811  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
112299400  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
Reference
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
dro03050  Proteasome
dro04650  Natural killer cell mediated cytotoxicity
dro04660  T cell receptor signaling pathway
KO pathway
ko04612   

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