KEGG   PATHWAY: dro04750
Entry
dro04750                    Pathway                                
Name
Inflammatory mediator regulation of TRP channels - Desmodus rotundus (common vampire bat)
Description
The TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive dorsal root ganglion (DRG) neuron cell bodies including their peripheral and central projections. These channels can be modulated indirectly by inflammatory mediators such as PGE2, bradykinin, ATP, NGF, and proinflammatory cytokines that are generated during tissue injury. While the noxious heat receptor TRPV1 is sensitized (that is, their excitability can be increased) by post-translational modifications upon activation of G-protein coupled receptors (GPCRs) or tyrosine kinase receptors, the receptors for inflammatory mediators, the same action appears to mainly desensitize TRPM8, the main somatic innocuous cold sensor. This aforementioned sensitization could allow the receptor to become active at body temperature, so it not only contributes toward thermal hypersensitivity but also is possibly a substrate for ongoing persistent pain.
Class
Organismal Systems; Sensory system
Pathway map
dro04750  Inflammatory mediator regulation of TRP channels
dro04750

Other DBs
GO: 0019233
Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112305173  KNG1; kininogen-1 isoform X1 [KO:K03898]
112305188  kininogen-1-like isoform X1 [KO:K03898]
112310964  BDKRB1; B1 bradykinin receptor [KO:K03915]
112311203  BDKRB2; B2 bradykinin receptor [KO:K03916]
112307665  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
112308251  HTR2C; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2C [KO:K04157]
112313639  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
112301248  HRH1; histamine H1 receptor [KO:K04149]
112316016  P2RY2; P2Y purinoceptor 2 [KO:K04269]
112300359  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
112296687  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
112311060  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
112311538  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
112311539  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
112321643  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
112308919  ALOX12; arachidonate 12-lipoxygenase, 12S-type isoform X1 [KO:K00458] [EC:1.13.11.31]
112304122  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
112311437  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
112304255  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
112317151  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
112309625  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
112318382  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
112302101  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
112297947  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
112297802  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112317227  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
112310655  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
112315574  TRPA1; transient receptor potential cation channel subfamily A member 1 [KO:K04984]
112308527  TRPV1; transient receptor potential cation channel subfamily V member 1 [KO:K05222]
112318305  ASIC1; acid-sensing ion channel 1 isoform X1 [KO:K04829]
112308603  ASIC2; acid-sensing ion channel 2 [KO:K04828]
112308343  ASIC3; LOW QUALITY PROTEIN: acid-sensing ion channel 3 [KO:K04830]
112308030  ASIC4; LOW QUALITY PROTEIN: acid-sensing ion channel 4 [KO:K04831]
112312682  ASIC5; acid-sensing ion channel 5 [KO:K04832]
112322988  CALML3; calmodulin-like protein 3 [KO:K02183]
112311702  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
112311250  CALM1; calmodulin-1 [KO:K02183]
112321120  calmodulin-like [KO:K02183]
112312926  CALM3; calmodulin-3 [KO:K02183]
112299615  CALML6; calmodulin-like protein 6 [KO:K02183]
112301078  calmodulin-beta-like [KO:K02183]
112297939  CALM2; calmodulin-2 [KO:K02183]
112305463  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
112306861  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
112312435  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
112319561  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
112302944  IL1B; interleukin-1 beta [KO:K04519]
112315147  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
112301004  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
112308621  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
112316519  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
112302047  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112321896  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112302140  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112322057  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
112296379  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112305558  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112317841  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112313781  NGF; beta-nerve growth factor [KO:K02582]
112315668  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
112303845  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
112300725  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
112310002  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112299448  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112307667  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112321016  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112305224  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112314466  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112301220  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
112303920  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
112307806  TRPM8; transient receptor potential cation channel subfamily M member 8 [KO:K04983]
112311151  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
112320979  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
112303826  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
112303827  neuroendocrine secretory protein 55-like [KO:K04632]
112306844  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
112321008  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
112297750  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
112300586  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
112320488  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
112318673  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
112296774  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
112315487  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
112298360  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
112309395  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
112301523  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112310589  TRPV4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
112307517  F2RL1; proteinase-activated receptor 2 [KO:K04234]
112300219  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
112314476  cytochrome P450 4A6 [KO:K07425] [EC:1.14.14.80]
112316515  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112304830  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
112321262  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112311270  PRKCH; protein kinase C eta type [KO:K18051] [EC:2.7.11.13]
112320743  PRKCQ; protein kinase C theta type isoform X1 [KO:K18052] [EC:2.7.11.13]
112321846  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
112308658  TRPV2; transient receptor potential cation channel subfamily V member 2 isoform X1 [KO:K04971]
112308804  TRPV3; transient receptor potential cation channel subfamily V member 3 isoform X1 [KO:K04972]
Compound
C00002  ATP
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00219  Arachidonate
C00388  Histamine
C00400  (-)-Menthol
C00469  Ethanol
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00780  Serotonin
C00808  (+)-Camphor
C00809  (-)-Camphor
C00903  Cinnamaldehyde
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04805  5(S)-HETE
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06254  Lysophospholipid
C06866  Capsaicin
C07600  Allicin
C09155  Phorbol
C09179  Resiniferatoxin
C09844  1,8-Cineole
C11695  Anandamide
C12083  (5Z,7E,9E,14Z,17Z)-Icosapentaenoate
C12271  N-Arachidonyldopamine
C14768  5,6-EET
C14769  8,9-EET
C19317  Allyl isothiocyanate
C20171  Icilin
C20698  2-Aminoethyl diphenylborinate
Reference
  Authors
Wang H, Woolf CJ
  Title
Pain TRPs.
  Journal
Neuron 46:9-12 (2005)
DOI:10.1016/j.neuron.2005.03.011
Reference
  Authors
Levine JD, Alessandri-Haber N
  Title
TRP channels: targets for the relief of pain.
  Journal
Biochim Biophys Acta 1772:989-1003 (2007)
DOI:10.1016/j.bbadis.2007.01.008
Reference
  Authors
Cheng JK, Ji RR
  Title
Intracellular signaling in primary sensory neurons and persistent pain.
  Journal
Neurochem Res 33:1970-8 (2008)
DOI:10.1007/s11064-008-9711-z
Reference
  Authors
Julius D
  Title
TRP channels and pain.
  Journal
Annu Rev Cell Dev Biol 29:355-84 (2013)
DOI:10.1146/annurev-cellbio-101011-155833
Reference
  Authors
Patapoutian A, Peier AM, Story GM, Viswanath V
  Title
ThermoTRP channels and beyond: mechanisms of temperature sensation.
  Journal
Nat Rev Neurosci 4:529-39 (2003)
DOI:10.1038/nrn1141
Reference
  Authors
Dhaka A, Viswanath V, Patapoutian A
  Title
Trp ion channels and temperature sensation.
  Journal
Annu Rev Neurosci 29:135-61 (2006)
DOI:10.1146/annurev.neuro.29.051605.112958
Reference
  Authors
Story GM
  Title
The emerging role of TRP channels in mechanisms of temperature and pain sensation.
  Journal
Curr Neuropharmacol 4:183-96 (2006)
DOI:10.2174/157015906778019482
Reference
  Authors
Velazquez KT, Mohammad H, Sweitzer SM
  Title
Protein kinase C in pain: involvement of multiple isoforms.
  Journal
Pharmacol Res 55:578-89 (2007)
DOI:10.1016/j.phrs.2007.04.006
Reference
  Authors
Zhang X, Huang J, McNaughton PA
  Title
NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels.
  Journal
EMBO J 24:4211-23 (2005)
DOI:10.1038/sj.emboj.7600893
Reference
  Authors
Bessac BF, Jordt SE
  Title
Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.
  Journal
Physiology (Bethesda) 23:360-70 (2008)
DOI:10.1152/physiol.00026.2008
Reference
  Authors
Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andre E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P
  Title
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.
  Journal
Proc Natl Acad Sci U S A 104:13519-24 (2007)
DOI:10.1073/pnas.0705923104
Reference
  Authors
Latorre R, Brauchi S, Madrid R, Orio P
  Title
A cool channel in cold transduction.
  Journal
Physiology (Bethesda) 26:273-85 (2011)
DOI:10.1152/physiol.00004.2011
Reference
  Authors
Babes A, Ciobanu AC, Neacsu C, Babes RM
  Title
TRPM8, a sensor for mild cooling in mammalian sensory nerve endings.
  Journal
Curr Pharm Biotechnol 12:78-88 (2011)
DOI:10.2174/138920111793937835
Reference
  Authors
Loyd DR, Henry MA, Hargreaves KM
  Title
Serotonergic neuromodulation of peripheral nociceptors.
  Journal
Semin Cell Dev Biol 24:51-7 (2013)
DOI:10.1016/j.semcdb.2012.09.002
Reference
  Authors
Grant AD, Cottrell GS, Amadesi S, Trevisani M, Nicoletti P, Materazzi S, Altier C, Cenac N, Zamponi GW, Bautista-Cruz F, Lopez CB, Joseph EK, Levine JD, Liedtke W, Vanner S, Vergnolle N, Geppetti P, Bunnett NW
  Title
Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice.
  Journal
J Physiol 578:715-33 (2007)
DOI:10.1113/jphysiol.2006.121111
Reference
  Authors
Mandadi S, Armati PJ, Roufogalis BD
  Title
Protein kinase C modulation of thermo-sensitive transient receptor potential channels: Implications for pain signaling.
  Journal
J Nat Sci Biol Med 2:13-25 (2011)
DOI:10.4103/0976-9668.82311
Related
pathway
dro00590  Arachidonic acid metabolism
dro04010  MAPK signaling pathway
dro04020  Calcium signaling pathway
KO pathway
ko04750   

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